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Ph.D. Students on Biomechanical Modelling and GUI design for Deformable Image Registration

In this project, we aim to go beyond the proof-of-concept stage of a novel, multi-objective, approach to deformable image registration for which a pilot …

2 maanden geleden


Meibergdreef, Amsterdam, Noord-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
€ 2336 - € 2992 per maand


In this project, we aim to go beyond the proof-of-concept stage of a novel, multi-objective, approach to deformable image registration for which a pilot implementation was previously made by the Amsterdam UMC, location Academic Medical Center (AMC) and Centrum Wiskunde & Informatica (CWI; the Dutch national research institute for mathematics and computer science). In multi-objective optimization, a set of solutions that represents efficient trade-offs between the objectives is computed and presented at once.

We will focus on the utilization of this approach within a key medical area that stands to benefit from accurate deformable image registration: radiation therapy. With this project we wish to truly bridge the gap between theoretically powerful deformable image registration software and real-world practically (i.e., clinically) useful software tools to realize the true potential of deformable image registration for radiation therapy and ultimately improve the treatment (i.e., make radiation therapy more effective thereby reducing mortality rate and adverse side effects). We aim to arrive at a stage of development where commercial parties will be interested to integrate our technology within their software.

We currently specifically seek candidates for two subprojects:

  1. Building and validation of biomechanical deformation models that

    1. can cope with large deformations (including e.g., sliding tissues) and content mismatches, and

    2. can be efficiently optimized over by the evolutionary algorithms, and

    3. can be instantiated by machine-learning techniques.

  2. Design, development, and validation of a graphical user interface (GUI) and software system to present the set of registration solutions (i.e., trade-offs) intuitively and to ensure insightful and fast navigation so that the best solution can easily be selected by medical experts. This research will be done in close collaboration with potential users: medical experts at AMC, including radiation oncologists, clinical physicists, and radiation therapy technologists.

This project will ultimately consist of four full-time research positions and a part-time radiation therapy technologist position.


Candidates are required to have an M.Sc. degree in computer science, physics, or similar areas with relevant experience, and a clinical research interest. If you are obtaining your M.Sc. degree before April 2019, you are also invited to respond.

It is essential that you have a clear interest in working both on fundamental research as well as on applying this research, in collaboration with academic partners and company partners. We expect a flexible, can-do mentality and attitude with a willingness to cooperate with experts across different disciplines (including computer science, physics, and medicine). Further, you are highly motivated to develop your skills as an independent researcher.

Applicants are required to have substantial programming skills (C/C++ experience is a pre). Applicants are further expected to have an excellent command of English.


Working at the AMC means working in an inspiring and professional environment in which developing one’s talents and skills is encouraged.

We offer a fixed term full-time contract for 1 year, which under normal circumstances will be prolonged with 3 years. The salary is in accordance with the Collective Labor Agreement for University Medical Centers in the Netherlands (CAO-UMC).

A PhD student (Onderzoeker in Opleiding) is placed in scale 21, with a full-time gross monthly salary that ranges from € 2336,- to € 2992,-.

The applicant will get a contract through the AMC Medical Research BV., which includes a payment of holiday allowance of 8% and a year-end bonus of 8.3% of the gross yearly salary.

Additional information

If you wish to apply for this position, click on the ‘Solliciteren’ button. For further information about the position, please contact Tanja Alderliesten (e-mail: t.alderliesten@amc.uva.nl).

A complete application includes a letter of motivation including research interests and reasons for applying, a detailed resume, and a list of courses followed (at B.Sc. and M.Sc. level) including obtained grades.

The starting date is flexible, from March 1, 2019 onward. Candidates who have not yet completed their M.Sc. but will do so before the end of April 2019 are also invited to apply.