PhD student position: Huntington’s Disease and the Ubiquitin-Proteasome System

Huntington’s Disease is caused by the accumulation and aggregation of mutant Huntington protein (mHtt) fragments in neuronal cells. Improving the clearance of …

18 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Meibergdreef, Amsterdam, Noord-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Opleidingsniveau:
WO

Functieomschrijving

Huntington’s Disease is caused by the accumulation and aggregation of mutant Huntington protein (mHtt) fragments in neuronal cells. Improving the clearance of mHtt prior to aggregation is a therapeutic strategy to prevent or delay the disease.

Our group focuses on the role of the ubiquitin-proteasome system (UPS) as we aim to improve recognition and degradation of mHtt by the proteasome prior to aggregation. We showed that proteasomes are not impaired by mHtt aggregates and are able to degrade mHtt. Interestingly, proteasome complex formation changes during HD progression in affected brain areas, but also in brain areas where huntingtin is expressed but no aggregation is observed. We aim to examine the effects of these changes in more detail in order to improve proteasome functioning in HD.

You will work in a research team working on Htt ubiquitination and degradation, using biochemistry, proteomics and microscopy, and will be working with a postdoc and technician on this project.

Functie-eisen

The PhD student should have studied BioMedical Sciences or a related study with experience in biochemistry.

Conditions

We offer a salary conforming to the Collective Labor Agreement for University Medical Centers in the Netherlands (CAO UMC) with a range of added fringe benefits, such as an annual bonus of 8.3%, holiday allowance, collective discounted rates for a number of insurances, an attractive bicycle scheme and/or public transport allowance, and free parking. You will be employed by the AMC Medical Research BV.

PhD students (Onderzoeker in Opleiding) are placed in scale 21, with a fulltime gross salary that ranges from € 2.279,- to € 2919,- and is based on qualifications and experience.

Starting date is ideally September 2018 for a period of 4 years.

Additional information

If you wish to apply for this position, click on the ‘Solliciteren’ button.

For more information about this vacancy you may contact Prof Eric Reits,e-mail: e.a.reits@amc.uva.nl, https://www.medischebiologie.nl/reits-group/

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