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PhD student

Peptide receptor radionuclide scintigraphy and peptide receptor radionuclide therapy are methods successfully applied in the clinic for imaging and treatment …

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
's-Gravendijkwal, Rotterdam, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2495 - € 3196 per maand
Opleidingsniveau:
WO

Functieomschrijving

Peptide receptor radionuclide scintigraphy and peptide receptor radionuclide therapy are methods successfully applied in the clinic for imaging and treatment of various cancer types. For this, radiotracers are applied that target specific molecules overexpressed on cancer cells. Unfortunately, not all tumor types have high expression of suitable target molecules on their cell surface. Many tumors are surrounded by tumor stroma which forms a barrier around the cancer cells and thereby makes it difficult for anti-cancer drugs to reach these cells. A very novel and promising approach is to target cells present in the tumor stroma with radiotracers and hereby indirectly visualize and/or treat the cancer. This strategy can be applied for imaging and treatment of multiple tumor types in which the specific stroma component that the radiotracer is directed against is present. Furthermore, the stroma barrier now becomes the tool to deliver cytotoxic irradiation to cancer cells to eliminate them.

The aim of this preclinical project is to develop and apply a novel imaging and treatment strategy by targeting cells present in the tumor stroma with novel radiotracers directed against tumor stroma components. These novel radiotracers are currently being developed in our lab. The PhD student will design and execute studies to evaluate and apply the newly developed radiotracers for imaging and treatment of multiple tumor types. The project will involve in vitro cell and tissue assays, in vivo experimentation in mouse models of cancer and histological examination of tumor tissue.

Functie-eisen

  • You are a highly motivated candidate with a university MSc degree.
  • You have outstanding theoretical and experimental research skills, are well organized and result-driven with a strong team spirit.
  • You have strong English skills (both written and oral).
  • You have received excellent scientific training in the field of (molecular) biology, oncology, or a related field.
  • Experience with animal studies, radiolabeling and radionuclide imaging will be considered an advantage.

Conditions

The appointment is available from November 1st, 2020. You will receive a temporary position for 4 years. The monthly salary is about € 2.495 in the 1st year, it increases to about € 3.196 in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Additional information

For more information about this position, please contact Prof. dr. Marion de Jong (project leader), phone number: +31(0) 6 215 353 22, e-mail: m.hendriks-dejong@erasmusmc.nl or Dr. Simone Dalm (project leader), phone number: + 31 (0)10 704 1033 or e-mail: s.dalm@erasmusmc.nl.

Your application must include the following documents:
  • Cover letter explaining your motivation and suitability for the position.
  • CV/resume including your final marks, research projects and other relevant experience
  • Contact information of 2 senior scientists or principle investigators as references, willing to provide recommendation letters or enquiry.
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