1 dag geleden - VU - Amsterdam
The Vrije Universiteit Amsterdam School of Business and Economics established the Hermine Weijland Fellowship in 2017 with the aim of attracting and promoting …
Hyperthermia (HT) - temporary elevation of tumor temperature to 41-43 °C - inhibits repair of DNA double-strand breaks (DSBs) by targeting the BRCA2 protein, …
Hyperthermia (HT) - temporary elevation of tumor temperature to 41-43 °C - inhibits repair of DNA double-strand breaks (DSBs) by targeting the BRCA2 protein, making it a powerful radio- and chemosensitizer with proven clinical track record. However, the efficacy of HT treatments can be negatively affected by insufficient thermal dose delivery, temporary nature of HT effects and induction of thermotolerance (temporary resistance to subsequent HT treatments). Recently, we found that inhibition of the chaperone HSP90 enhances the effects of HT treatments in vitro, without affecting non-heated cells, establishing it as a straightforward, safe and efficient approach to improve HT treatment efficacy.
In the first phase of the current project, the candidate will further investigate the mechanisms driving cellular responses to HT and HSP90 inhibition, in order to rationally optimize radio/chemo-sensitization protocols and reduce thermotolerance in vitro. The candidate will also apply advanced mass spectroscopy approaches to determine the effect of HT and HSP90i on the proteome. In the second part of the project, these molecular insights will be extended to animal models of cancer, with the aim of fast clinical introduction of HSP90i-assisted hyperthermic anticancer therapies.
We are seeking a hard-working, flexible, independent and motivated candidate holding a MSc degree in Biomedical Sciences (or equivalent), with ample research experience in (Molecular) Cell Biology, preferably in the fields of Oncology and/or Mass Spectroscopy. The ability to work in a team and excellent verbal and written English skills are a must.
Being able to present a certificate of good conduct is a condition for the appointment.