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  3. PhD student on theranostic agents for breast cancer imaging and therapy

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PhD student on theranostic agents for breast cancer imaging and therapy

Applications are invited for a highly motivated and enthusiastic PhD student position to contribute to the research of the RadioPharmaceutical Chemistry (RPC) …

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
's-Gravendijkwal, Rotterdam, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 1912 - € 2704 per maand
Opleidingsniveau:
WO

Functieomschrijving

Applications are invited for a highly motivated and enthusiastic PhD student position to contribute to the research of the RadioPharmaceutical Chemistry (RPC) Group. You will work on a project aiming at the development of radiopharmaceuticals for targeted diagnosis and treatment of breast cancer.

Functional noninvasive nuclear imaging (i.e. SPECT, PET) can provide accurate assessment of receptor status in primary and metastatic lesions and facilitate personalized treatment planning. Yyou will develop a new generation of peptide-based theranostics pointing at two major Achilles' heels of breast tumors, namely the human epidermal growth factor receptor 2 (HER2) and the gastrin releasing peptide receptors (GRPR). The new radioactive drugs will be capable of providing adequate information about receptor status and subsequently kill the tumor cells when targeted radionuclide therapy is found appropriate.

As a PhD student you will be part of an interdisciplinary research group working in the field of Radiopharmaceutical Sciences. You will be directly responsible for the synthesis, radiolabeling and testing of the newly developed radiopharmaceuticals. Expertise in organic synthesis, analytical techniques (NMR, MS, HPLC) and radiochemistry is essential, together with some degree of cross-training in biology and pharmacology. Skill to design, synthesize and test novel radiopharmaceuticals will be sought. Evidence of a deep understanding of previous fields of research and of independent intellectual and practical contributions to previous research projects will be considered as indicators that such attributes can be brought to bear on the present project.

Functie-eisen

  • You are a highly motivated candidate with a university MSc degree.
  • You have received excellent scientific training in the field of Chemistry, Biochemistry or Pharmaceutical Sciences.
  • You have strong expertise in organic chemistry and analytical techniques (NMR, HPLC, MS)
  • You have eExperience with radiolabeling techniques, in vitro assays (binding affinity, internalization, cell uptake, etc.) and in vivo biological studies (biodistribution, metabolite studies, etc.) is an asset.
  • You have outstanding theoretical and experimental research skills.
  • You are result-driven with a strong team spirit.
  • You are able to work both independently and in a multidisciplinary team.
  • You have excellent communicative, cooperative and organizational skills;.
  • You have strong English language skills (written and oral).

Conditions

You will receive a temporary position for 4 years. The gross monthly salary is € 2.495,- in the 1st year and increases to € 3.196,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Additional information

For more information about this position, please contact Yann Seimbille, Assistant Professor and Head of RadioPharmaceutical Chemistry, e-mail: y.seimbille@erasmusmc.nl. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, by phone number: +31 (0)6 500 310 06.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.