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  3. Postdoctoral Research Scientist for research in applied epigenetics and epigenomics

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Postdoctoral Research Scientist for research in applied epigenetics and epigenomics

We are looking for a highly motivated, self-driven and creative recent PhD graduate to join the Applied Epigenomics group of the Department of Genetic …

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
's-Gravendijkwal, Rotterdam, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2911 - € 4615 per maand
Opleidingsniveau:
WO

Functieomschrijving

We are looking for a highly motivated, self-driven and creative recent PhD graduate to join the Applied Epigenomics group of the Department of Genetic Identification at Erasmus MC, led by Dr. Athina Vidaki. The successful candidate will be offered a postdoc position for 12 months, which, subject to satisfactory progress and funding availability, could be further extended. You will contribute to our recently funded research by the Dutch Research Council (NWO), which aims to further develop and test an innovative method for the standardization of bisulfite conversion-based epigenetic/epigenomic methods. Additionally, as part of an interdisciplinary research group working in the field of applied (epi)genomics you will also be expected to contribute to other ongoing projects.

Our environment, lifestyle choices and disease status influence our genome via chemical DNA modifications such as DNA methylation. To translate DNA methylation to DNA sequence variation, scientists treat DNA with sodium bisulfite, a harsh chemical process known to cause DNA fragmentation and loss. Despite the popularity of this approach, no analytical method exists so far that can assess this conversion process. Lacking information regarding the quality and quantity of bisulfite-converted DNA, subsequent analysis can lead to inaccurate results and misleading outcomes, especially in challenging applications with low-quantity/quality DNA such as in forensics. Our group has invented the first-of-its-kind, cost-effective and robust solution to this problem, which recently resulted in a patent application.

As a postdoc in this project, you will directly be responsible for the further development, optimization, validation and testing of the proposed novel and innovative method using various popular detection systems. Thus, it is important that you are familiar with assay development and standardized laboratory procedures. Very importantly, you will manage a project which is in collaboration with various network partners; >15 labs including other departments at Erasmus MC and international organizations. Therefore, it is essential that you are experienced with day-to-day project management and that you have excellent organization and communication skills. As the main scientist in this project, you will not only be given the chance to significantly expand your local and international professional network, including industrial and governmental parties, but also gain insights on the valorisation process of a technology, all way down to the eventual commercialization of the method by a third (commercial) party.

As a postdoc within the Applied Epigenomics group you will also be expected to perform key researcher activities, including keeping up with current literature and analysis tools in the project area, maintaining meticulous lab book and results reporting (including contributing to preparation of official documents to NWO), supporting other team members and students, actively engaging in interdisciplinary research, contributing towards organizing events, writing scientific publications and collaborating in proposal writing as part of new funding seeking.

Functie-eisen

  • You are a highly motivated candidate with a successfully completed university PhD degree.
  • You have received excellent scientific training as part of a PhD in the field of Molecular Biology, Biochemistry or (Epi)genetics from an internationally highly recognized university.
  • You have a strong interested in applied research and technological innovation.
  • You have outstanding theoretical and experimental research skills in study design, execution and analysis.
  • You have at least one publication in a peer-reviewed scientific journal as leading (first) author.
  • You are able to develop innovative ideas as part of your assigned project but also for the development of a future research line.
  • You have mastered molecular biology techniques in previous research projects, such as DNA extraction, DNA quantification, (q)PCR, gel electrophoresis, fragment analysis, library preparation, next-generation sequencing, etc.; experience with epigenetic techniques is an asset.
  • You have experience in PCR design and assay development/validation.
  • You have sound knowledge in bioinformatics and biostatistics; experience with dry-lab research is an asset.
  • You are result-driven with a strong team spirit.
  • You are able to work both independently and in a multidisciplinary team with minimal supervision; experience working within interdisciplinary teams is an asset.
  • Experience in teaching and supervising students is a plus.
  • You have excellent communicative, collaborative and organizational skills.
  • You have strong written and oral English language skills (working language in the Department).

Conditions

The position is available for 1 year. The gross monthly salary amounts a maximum of € 4.615,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Additional information

For more information about this position, please contact Dr. Athina Vidaki, Senior Postdoctoral Research Scientist, e-mail: a.vidaki@erasmusmc.nl. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, by phone number: +31 (0)6 500 310 06.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.