3 dagen geleden - Universiteit van Amsterdam (UvA) - Amsterdam
The Amsterdam School for Cultural Analysis, one of six research schools of the Faculty of Humanities, has a vacant PhD position as part of the ERC …
A new and exciting research collaboration between Eindhoven University of Technology and Erasmus Medical Center focuses on the development of the 'plaque-on- …
A new and exciting research collaboration between Eindhoven University of Technology and Erasmus Medical Center focuses on the development of the 'plaque-on-a-chip' model. We are seeking an ambitious post-doc to develop this platform and generate unique experimental data.
Rupture of vulnerable atherosclerotic plaques is the underlying cause of the majority of acute cardiovascular events. Vulnerable plaques are characterized by the lipid-rich necrotic core which is separated from the arterial lumen by a thin fibrous cap. Rupture of the fibrous cap will expose the underlying necrotic tissue to blood, potentially leading to a thrombotic event. The process of plaque rupture is poorly understood. The goal of this project is to develop a plaque-on-a-chip model: an in vitro platform of a human-like atherosclerotic plaque to study plaque rupture.
We aim to create a reproducible and relevant analogue of a human vulnerable plaque that can be mechanically loaded, and visualized with microscopy. Plaque composition will be modulated with respect to collagen and smooth muscle cell concentration and organization. A necrotic core with tunable mechanical properties will be included in the construct. A straining device will be used to generate human smooth muscle cell-populated hydrogels to generate collagenous tissues with dimensions similar to human plaques. By using a light-inducible recombinant collagen hydrogel, the stiffness of the construct can be tuned locally to mimic a lipid core inside the plaque. The resulting plaque-on-a-chip will be subjected to rupture experiments.
We are accepting applications from enthusiastic candidates who are interested in a dynamic, stimulating and ambitious environment to perform their research. The candidate should have a PhD in Biomedical Engineering, or an equivalent area, with a background in soft tissue engineering and mechanics. The candidate should be able to effectively communicate scientific ideas, foster collaboration and have a capability for independent thinking. Moreover, the candidate should be able to work independently within a dynamic team and be skilled in written and spoken English.
Being able to present a certificate of good conduct, a valid proof of identity, diploma's and/ or relevant registration such as BIG/ RGS are conditions for the appointment.
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