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PhD Candidate 3D Radiation-dose Response Modeling for the Optic Tract and Eye

We are looking for a highly motivated candidate for a fully funded PhD project at the Department of Radiation Oncology. You will conduct research on how 3D radiation dose distributions can be correctly linked to the anatomy in the imaging data used to assess the radiation-induced damage, and research radiation-dose response modeling.

2 maanden geleden


Albinusdreef, Leiden, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
€ 2495 - € 3196 per maand


The research requires image registration of computed tomography (CT) imaging data and fundus photographs and optical coherence tomography imaging. After successful image registration, spatial dose metrics can be derived and used as input for 3D radiation-dose response modeling. You will further develop, validate, and compare normal tissue complication probability models for the optic tract and eye that are based on dose metrics, as well as clinical data. To this end, you will use standard logistic regression approaches and state-of-the-art machine learning.

In short

· You will be part of the project “Optical coherence tomography and widefield fundus photography for 3D radiation-dose response relationship in partial eye irradiation using in-patient comparison”

· You will use imaging data, radiation dose distribution data, and clinical data

· You will work on image registration and radiation-dose response relationship modeling

· You will work in a multidisciplinary, collaborative setting


You hold an MSc degree in computer science or similar area with relevant experience, and have an interest in research for clinical applications. If you expect to obtain your master’s degree before December 2020, you are also invited to apply. You have substantial programming skills and have an excellent command of English. It is essential that you have a clear interest in both working on fundamental research as its application in practice. We expect a flexible, can-do mentality and are looking for someone who is willing to collaborate with experts from different disciplines. Further, you are highly motivated to develop your skills as an independent researcher.


You will be employed on the basis of 36 hours per week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary will start with € 2,495 gross per month in the first year, amounting to a maximum of € 3,196 gross per month in the fourth year based on a fulltime position (scale for PhD students in the Collective Labour Agreement for University Hospitals).

Additional information

Career at the LUMC

The LUMC helps you with maintaining and developing your knowledge and expertise. We offer internal courses and in-service training to assist you with your personal development. We also offer services in terms of personal development, mobility and career advice.

Contac: Tanja Alderliesten, associate professor, Department of Radiation Oncology, email t.alderliesten@lumc.nl.