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PhD Candidate DNA Damage Repair in Cancer

The department of Human Genetics is looking for a PhD student who is intrigued to study mechanisms that prevent cancer development, has experience in fundamental cancer research and would like to be part of a young and dynamic team.

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 3020 - € 3020 per maand
Opleidingsniveau:
WO

Functieomschrijving

As a PhD student you will conduct a research project studying the role of BRCA1 protein complexes in homologous recombination. For this, you will study complex formation via proteomic approaches and the genetic interactions of the different complexes via genome-wide CRISPR-Cas9 screens. Furthermore, you will be involved in mechanistic studies on the effect of BRCA1 cancer mutations on genomic stability and will study the clinical relevance of these findings.

In short:

  • You received your MSc in molecular biology or a related field;

  • You have hands-on experience in standard molecular biology techniques;

  • You have an organized and independent work style and you have excellent communication skills;

  • You are motivated to study BRCA1 function in the maintenance of genomic stability.

Functie-eisen

You are an enthusiastic and driven early-career scientist who likes to work in a young and dynamic team, unravelling fundamental and mechanistic cancer research questions. You have hands-on experience in common molecular biology tools (molecular cloning, mammalian cell culture, Western blotting, fluorescent microscopy, flow cytometry, etc). Experience with CRISPR/Cas9-mediated genome editing is an advantage, but not a requirement. You are organized, accurate and able to work autonomously within a team. You have a flexible attitude, possess excellent communication skills and are fluent in written and spoken English.

Conditions

You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years (upon positive evaluation after year one), to be completed with a doctoral thesis. Your salary amounts to a maximum of € 2,357 gross per month in the first year, progressing to a maximum of € 3,020 in the fourth year (scale Pro, CLA UMC).

Additional information

Career at the LUMC

The LUMC helps you with maintaining and developing your knowledge and expertise. We offer internal courses and in-service training to assist you with your personal development. We also offer services in terms of personal development, mobility and career advice.

References will be requested.

Read more about the research group

Read more about the research theme: ‘Genome instability and cancer’

Contact: Dr. Sylvie Noordermeer, Department of Human Genetics