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  3. PhD Candidate on Chronic Kidney Disease in Diabetes Mellitus

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PhD Candidate on Chronic Kidney Disease in Diabetes Mellitus

As a PhD candidate you will be a part of our present research in which we aim to identify new players that might link Type 2 Diabetes Mellitus (T2DM), ethnicity and the risk of progression of chronic kidney disease (CKD). This is a collaborative project between Leiden University Medical Centre (LUMC

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 3020 - € 3020 per maand
Opleidingsniveau:
WO

Functieomschrijving

Gutmicrobiota and their diet-derived metabolites are increasingly important as drivers of cardiometabolic complications, in particular in patients with diabetes mellitus. However, the mechanisms underlying these detrimental effects on renal function in relation to different ethnic burden are still obscure. In our recent publication from the Healthy Life in an Urban Setting (HELIUS) study (a large multi-ethnic prospective cohort of 12.888 participants), we observed a clear ethnic inequality in prevalence of chronic kidney disease (CKD). In this regard, our recent data obtained from the previously mentioned HELIUS cohort, shows that the gut microbiota composition differs between different ethnicities.In the present research, we aim to identify new players that might link diabetes mellitus, ethnicity and the risk of CKD progression. This is a collaborative project between Leiden University Medical Centre and the Amsterdam University Medical Centre. You will be involved in pre-clinical studies aiming to unravel the underlying mechanisms of the microbiome-kidney axis in diabetic kidney disease: 1) to confirm ethnicity based difference in human microbiome and its effect on kidney function loss 2) to understand causality of CKD progression in diabetes mellitus 3) to explore the efficacy of therapeutic interventions using gut-microbiota to prevent progressive CKD in T2DM.

In short:

  • You have a master’s degree in a medical of biological subject

  • You will conduct research on chronic kidney disease in diabetes mellitus

  • You will be part of a collaborative project between the LUMC and Amsterdam UMC

Functie-eisen

You hold a master’s degree in Molecular Biology, Medical Biology, Biomedical Sciences, Biopharmaceutical Sciences, Medicine or a similar field. You have good laboratory skills and a natural curiosity. You are interested in both fundamental molecular biology and clinical translational research. An ability to work both independently and in collaboration with colleagues from different disciplines is essential. You have excellent communication skills in written and spoken English.

Conditions

You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is € 2,357 gross per month in the first year, amounting to € 3,020 in the fourth year (scale PhD students, CAO-UMC).

Additional information

The application procedure will involve you giving a presentation and references will be requested.

Career at the LUMC

The LUMC helps you with maintaining and developing your knowledge and expertise. We offer internal courses and in-service training to assist you with your personal development. We also offer services in terms of personal development, mobility and career advice.