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PhD Candidate Pathology

The LUMC is looking for a PhD candidate for a joint project focused on the development of mass spectrometry-based tools for the untargeted and in-depth characterization of epigenetic changes of bone tumours, specifically those on the histone level.

ongeveer een maand geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 3020 - € 3020 per maand
Opleidingsniveau:
WO

Functieomschrijving

In this joint PhD project between the Mass Spectrometry Imaging group of the Centre for Proteomics & Metabolomics, the Molecular Tumour Genetics group (research program Bone and Soft Tissue Tumours) of the Department of Pathology we are looking for a PhD candidate. The PhD program focusses on the development of mass spectrometry-based tools for the untargeted and in-depth characterization of epigenetic changes of bone tumours, specifically those on the histone level. Part of the work in this joint PhD project might be performed at the School of Chemistry University of Edinburgh (Edinburgh, Scotland). The project will include the in-depth characterization of cell-line derived histone proteoforms using top-down and middle-down proteomics approaches, but also the characterization of epigenetic and metabolic states upon treatment with epigenetic compounds. Furthermore we will assess the intratumour epigenetic and metabolic heterogeneity of various patient derived bone tumours using high-resolving power mass spectrometry imaging. The project will also include metabolic and epigenetic MSI-based characterization on tumours obtained from patients enrolled in a clinical trial. As a PhD student you will be responsible for acquiring the data and publication of the results. The project should be finalized with a thesis.
In short

  • You hold a relevant MSc-degree, or will obtain one shortly

  • You will be part of a highly multidisciplinary, international, collaborative project

  • You have an interest in mass-spectrometry

  • You will conduct research focused on bone tumours

  • Read the entire project description in the ‘More information’ section

Functie-eisen

You have obtained an MSc degree in Analytical Chemistry or a biomedical area (or will do so on very short notice). Furthermore, it is required that you have some experience with (MALDI) mass spectrometry and cell biological techniques, preferably in the field of oncology, and have good technical skills. It would be preferred if you also have some experience in computer scripting. You must be fluent in English, performance driven, structured and accurate and have good communication and writing skills.

Conditions

You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is € 2,357 gross per month in the first year, amounting to € 3,020 in the fourth year (scale PhD students, CAO-UMC).

Additional information

An assessment is part of the procedure, references will be requested and you will be asked to give a presentation.