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PhD Candidate Patient Sub-stratification in Acute Myeloid Leukemia

We are looking for a highly motivated candidate for a PhD project in Computational Oncology at the department of Biomedical Data Sciences. This project focusses on the integrative analysis of multiple types of omics data to improve diagnosis, prognosis and predicted treatment outcomes of patients with acute myeloid leukemia.

ongeveer een maand geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 2495 - € 3196 per maand
Opleidingsniveau:
WO

Functieomschrijving

Acute myeloid leukemia (AML) is a cancer of the myeloid blood lineage that typically affects elderly patients. Current efforts for a personalized prognosis and treatment focus on the detection of just a few genetic aberrations, thereby ignoring the overwhelming evidence that AML is mostly driven by epigenetic and metabolic factors. Within the newly established Leiden Center for Computational Oncology, acute myeloid leukemia was chosen as one of the projects to spearhead the development of novel computational tools that support personalized medicine beyond the 'one-mutation one-drug' paradigm. Hence, within this project, you will be employing molecular data created from clinical material to capture multiple regulatory levels (genetics, transcriptomics, metabolomics, proteomics) to improve patient stratification, prediction of treatment responses and identification of novel therapeutic targets. The activities of the PhD candidate are purely computational and will be embedded within the Leiden Computational Biology Center (prof. M. Reinders), and the department of Hematology (prof. H. Veelken MD). 

In short

·         You will work on the deep molecular characterization of acute myeloid leukemia, to identify clinically relevant sub-entities of the disease, actionable determinants of treatment resistance and potential targets for immuno-therapy

·         You will work in a multi-disciplinary environment ranging from data science to translational oncology within the recently established Leiden Center for Computational Oncology

·         You will disseminate your work by writing scientific manuscripts and presenting your research at international conferences. The combination of this work will lead to a PhD title

Functie-eisen

You hold a MSc degree in Bioinformatics, Statistics, Life Sciences, or a similar area. You possess a strong background in data analytics, have hands-on experience with applying machine learning methods, and you are familiar with scripting languages such as R or Python. Knowledge of genetic analyzation and transcriptomic studies are favored but not required. You enjoy the pursuit of knowledge across multiple field, and you have an optimistic and kind nature.

Conditions

As a PhD candidate, you will be appointed for the duration of four years. Your salary is a maximum of € 2,495 in the first year, amounting to a maximum of € 3,196 in the final year (scale PhD students, Collective Labour Agreement University Medical Centers).

Additional information

Your career at the LUMC

The LUMC offers opportunities to maintain and develop your knowledge and skills. We offer internal courses and in-service training to help you with your personal development. We also offer services for mobility and career advice. 

Contact details
Erik van den Akker, Computational Biologist, Department of Biomedical Data Sciences

+31(0)71 526 85 57.
e.b.van_den_akker@lumc.nl