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PhD candidate Spatial Gene Expression and Transcriptional Regulation in Muscular Dystrophies

Looking for an interesting research opportunity? We are looking for an enthusiastic PhD candidate to study spatial gene expression and transcriptional regulation in muscular dystrophies.

7 maanden geleden


Albinusdreef, Leiden, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
€ 2422 - € 3103 per maand


You will work in a team that studies muscular dystrophies such as Duchenne muscular dystrophy (DMD). In these patients, genetic mutations lead to muscle weakness and progressive loss of motor skills eventually leading to wheelchair dependency and death. The reduction of force is mirrored by the replacement of muscle mass by adipose tissue, affecting the contractile capability of skeletal muscle. In this project you will study spatial distribution of gene expression in muscle tissue of multiple forms of muscular dystrophy to understand the mechanism behind the conversion of muscle mass into adipose tissue. You will work in a multi-disciplinary team, interacting with molecular biologists, bioinformaticians, radiologists and neurologists.


You should have a master degree in biomedical sciences, molecular biology, bioinformatics or a related field. A solid background in molecular biology and experience with data analysis are advantageous. You are a quick learner, with excellent communication skills in English. You will work in an international team, use state of the art sequencing and molecular biology technologies, present data and write articles. Most importantly, you are highly motivated, perseverant, a high achiever and you are a team player.


You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is € 2,422 gross per month in the first year, amounting to € 3,103 (scale PhD students, CLA UMC).

Additional information

Contact: Pietro Spitali, assistant professor, Department of Human Genetics, telephone: +31(0)71 526 94 37.