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PhD Candidate T Cell Receptor Gene Therapy

We are looking for an enthusiastic PhD candidate to join our team and carry out the HA-1H T cell receptor gene therapy study in patients with hematological malignancies, which starts in July 2020.. Are you interested in immune therapy and how to translate laboratory findings into clinical practice? Then we are looking for you!

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Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 4615 per maand
Opleidingsniveau:
WO

Functieomschrijving

Immune therapy is a treatment used to strengthen and manipulate the immune system of patients to fight cancer. Recently, clinical studies have shown that genetically modified immune cells can be active in patients with cancer. These treatments aim to target proteins on the cancer cells by the immune cells, after which the cancer cells are eliminated. For this treatment, the immune cells are equipped with a variety of identification structures with the aid of gene therapy. These structures are: chimeric antigen receptors (CAR) or T cell receptors (TCR). Recently, our research group carried out a TCR gene therapy study in patients with leukemia after allogeneic stem cell transplantation. This study showed that it was possible to produce the genetically modified T cells under Good Manufacturing Practice (GMP) conditions and that they could be safely administered to patients. Together with the Company Medigene AG, in  our new HA-1H TCR gene therapy study, we want to treat patients with recurring or persistent leukemia with an optimized HA-1H TCR product and treatment strategy. For this study, you will  interact with other academic institutions in the Netherlands to recruit patients and logistically arrange the inclusion of these patients. You will participate in the GMP production of the TCR modified cell product and the monitoring and evaluation of patients after infusion of the genetically modified T cells. You will work on further refining and optimizing these cellular therapies.

Functie-eisen

We are looking for a driven candidate with a master’s degree in medicine. You have an interest in immunology and hematology. Laboratory experience in the area of immunology is advantageous. We are looking for a candidate with a proactive work approach who is able to collaborate with researchers, clinicians, research technicians, care workers as well as people from the corporate environment.

Conditions

As a PhD candidate with a background in medicine, you will be appointed for a maximum of 4 years, which should lead to a doctoral thesis. The salary is based on your experience and education and amounts to a maximum of € 4.,615 gross per month, based on a fulltime position (scale 10, cla UMC).

Additional information

References can be requested as part of the procedure.

The position starts September 1st, 2020.

You can also contact Peter van Balen, hematologist at the Department of Hematology, telephone +31(0)71 526 22 71.

Contact

Dr. Mirjam Heemskerk, associate professor at the Department of Hematology, telephone +31(0)71 526 32 07.