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PhD student Genomics of cardiovascular disease (m/f)

While cardiovascular diseases continue to be the main cause of death worldwide, therapies focusing on lowering cholesterol are reaching their maximum …

4 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 2279 - € 2919 per maand
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

While cardiovascular diseases continue to be the main cause of death worldwide, therapies focusing on lowering cholesterol are reaching their maximum efficacy. As a PhD student you will aim to discover novel coding and non-coding RNAs in immune cells that drive the formation of atherosclerotic plaques in coronary arteries. Specifically, you will use cell culture models and unique biomaterial of patients to identify distinct gene expression signatures of immune cells (e.g. T-cells) upon exposure to lipids (e.g. triglycerides) that impact atherosclerosis. An exciting aspect of this project is that you will employ single-cell sequencing to gain optimal mechanistic insight. To further define the RNAs as potential targets for cardiovascular treatment, you will apply advanced causal inference methods to large-scale in-house (e.g. BIOS) and public data resources (e.g. UK Biobank). Your project will be embedded in the nation-wide GENIUS consortium that aims to develop new druggable targets for cardiovascular disease in immune cells.

Functie-eisen

You hold a Master’s degree in (medical) biology, life sciences or a comparable subject. You have a sharp and creative mind, can effectively collaborate with researchers from other disciplines, and have demonstrable affinity with statistical/bioinformatics data-analysis.. Furthermore, experience with genome technologies (e.g. microarrays or next-generation sequencing), cell culture techniques, and/or software for data-analysis (e.g. ‘R’) will be an advantage. If you recognize yourself in the profile, we look forward to receiving your application. Please, make sure to include a personal statement of interest.

Conditions

You will be employed on the basis of a 36-hour week for the duration of the PhD research (four years). Your salary is € 2,279 gross per month in the first year, progressing to € 2,919 gross per month in the fourth year based on a full-time position (scale PhD students of the Collective Labour Agreement for University Hospitals).

The terms of employment offered by the LUMC are highly favorable. For example, you will receive 8% holiday remuneration, a year-end bonus, and a pension arrangement with the National Civil Pension Fund. Also, as employee of one of the University Hospitals in the Netherlands, you can benefit from our collective health insurance policy.

Moreover, the LUMC offers excellent facilities in the area of education, child-care centers, and career advice. In addition, you may enjoy various leave arrangements and other extras. You can read more about these facilities elsewhere on this site.

Additional information

If you have any questions, or if you want more information about this position, please contact Dr. Bas Heijmans, Principal Investigator, Biomedical Data Sciences, telephone 071 526 97 85, email b.t.heijmans@lumc.nl. References will be requested and you will be asked to give a presentation.