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Postdoc Cell and Chemical Biology Department

Are you looking for an interesting postdoc position in cell and chemical biology? We are looking for a postdoc to work on a project aimed at chemical biological approaches to redirect TGF- signaling.

ongeveer een maand geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 4481 per maand
Opleidingsniveau:
WO

Functieomschrijving

Transforming growth factor-b (TGF-b) is of key importance in development and maintenance of tissue homeostasis. Work in the Ten Dijke lab is focused on the understanding how TGF-β signaling is perturbed in cancer, and to find new ways to target this pathway for therapeutic gain. In this role you focus on the development of synthetic bioactive molecules that selectively modulate protein-protein interactions or enzymatic activities involved in TGF-b signaling. Examples of such molecules include nanobodies, macrocyclic kinase inhibitors, PROTACs (Proteolysis targeting chimeric molecules) and modulators of the ubiquitin machinery. 

As a team we take a multidisciplinary approach, including high-throughput chemical screens, genetics, (bio)chemistry, cell biology, zebrafish/mouse models and mathematics and bioinformatics.

In short

·        You have a PhD degree in chemical or molecular cell biology

·        You will work on redirecting TGF-b signaling

·        You have multiple years of experience and expertise in the subject and as a researcher

Functie-eisen

You hold a PhD in chemical or molecular cell biology. You have expertise in biochemistry and multiple years of experience. You are highly motivated with proven research abilities and an excellent publication record. Furthermore, you are willing and able to work both independently and also collaboratively as part of a team.

Conditions

You will be employed on the basis of 36 hours per week. Appointment is for two years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

Additional information

For further information, please visit our department website: https://ccb.lumc.nl/ and Chemical Signaling lab web site: https://ccb.lumc.nl/about-the-ten-dijke-lab-34

Literature

Xie F, Jin K, Shao L, Fan Y, Tu Y, Li Y, Yang B, van Dam H, ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F, Zhang L. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nat Commun. 2017 8:15021 (2017).

Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L, ten Dijke P. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J. 36(11):1623-1639 (2017).

Hawinkels LJ, de Vinuesa AG, Paauwe M, Kruithof-de Julio M, Wiercinska E, Pardali E, Mezzanotte L, Keereweer S, Braumuller TM, Heijkants RC, Jonkers J, Löwik CW, Goumans MJ, ten Hagen TL, ten Dijke P. Activin receptor-like kinase 1 ligand trap reduces microvascular density and improves chemotherapy efficiency to various solid tumors. Clin Cancer Res. 22(1):96-106 (2016).

Contact: Peter ten Dijke, professor and section head, Department of Cell and Chemical Biology, telephone +31(0)71 526 92 71.

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