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Postdoc in TGF-b Signaling and Chemical Biology

Do you have a PhD in (bio)chemical or molecular cell biology and are you interested in studying the molecular basis of subverted TGF- signal transduction in human diseases? Then we have an interesting postdoc position for you.

5 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

Misregulation of TGF-b signalling has been implicated in many different diseases, including cancer, fibrosis and cardiovascular diseases. We have performed genetic gain and loss of function genetic and proteomic screens to identify novel druggable regulators of TGF-β pathways. In this project the mechanism of action and importance in disease of these novel regulators will be elucidated. In addition, we will harness the ubiquitin machinery (e.g. using PROTACs) to induce degradation of critical pro-oncogenic factors. You will contribute to this project.

Functie-eisen

We are searching for a highly motivated and experimentally talented scientist with drive to answer important fundamental research questions. You should hold a recent PhD and have a strong background in biochemistry and/or molecular cell biology. In addition, you have previous experience in signal transduction or chemical biology. Reporting and publishing the results in high impact scientific journals and at international conferences is expected.

Conditions

You will be employed on the basis of a 36-hour week. Appointment will be for 2 years, possibly to be extended. The salary will depend on your qualifications and experience, with a maximum of € 4,481 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

Additional information

The employment is initially for a period of two years with possibility for extension.

References will be requested as part of the application procedure. You will also be asked to give a presentation and an assessment will be part of the procedure.

References

Zhang Z et al. . Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nat Commun. 2017 Dec 13;8(1):2116.

Zhou F et al. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO J. 2017 Jun 1;36(11):1623-1639.

Zhang L. et al. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Mol Cell. 2013 51:559-72

Zhang X et al. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J. 2013 32:996-1007.

Contact: Peter ten Dijke, professor / section head, Department of Cell and Chemical Biology, telephone +31(0)71 526 92 71, email p.ten_dijke@lumc.nl