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Postdoc Next Stage Development of the Novel Synthetic Antimicrobial Peptide SAAP-148

The emergence of antimicrobial resistance (AMR) worldwide raises fears of untreatable infections. If current trends continue it has been estimated that 10 million people will be dying as a result of AMR in 2050. In an attempt to prevent this dark scenario we have developed a novel agent, i.e. the synthetic antibacterial and anti-biofilm peptide (SAAP)-148, that is highly effective against AMR bacteria and biofilms. In this project we will develop chemical modifications to increase peptide’s stability and ability to penetrate cells, while minimizing its side effects. As a postdoc, you will contribute to this research.

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Salarisindicatie:
€ 4615 per maand
Opleidingsniveau:
WO

Functieomschrijving

You will contribute to developing several strategies, e.g. nanoparticles and mesoporous silica particles, to optimize the delivery of SAAP-148 deep into wounds with a controlled release over time in parallel. Efficacy of combinations of optimal formulations and peptide modifications will be investigated in preclinical models for chronic wound infections. Successful combinations will be available for clinical trials. Among other tasks, you will focus on developing an animal model for diabetic wounds and providing proof-of-concept for the selected combinations of formulation and SAAP-148 modifications after injection in deeper layers of tissues/wounds. Finally, you will develop/optimize and pre-clinically test controlled release systems for application of antimicrobial peptides, like SAAP-148 in deeper layers of tissues/wounds.    

In Short

·         You will be a postdoc at an academic, international and multidisciplinary environment

·         Your main tasks are developing animal models for diabetic wounds, providing proofs-of-concept and develop/optimize and pre-clinically test controlled release systems

·         You will work at various institutions

 

 

Functie-eisen

You hold a doctorate in the area of life sciences and technology, biopharmaceutical sciences, chemistry, biomedical sciences, medical technology, or related fields. You also have an interest in multidisciplinary research (animal models, formulation of antimicrobial agents, bacteria and immunology) and an insatiable thirst for new knowledge. You have great confidence in working with animals, a variety of chemical equipments and computers, and are willing to spend extended periods at different research locations.

Conditions

You will be employed on the basis of 36 hours per week. Appointment is for two years. Your salary is based on your education and experience and is a maximum of  € 4,615  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

Additional information

Your career at the LUMC

The LUMC stimulates you in maintaining and developing your knowledge and skills. We offer internal courses and continuous training as well as services in terms of mobility, personal development and career advice.

Contact: Peter Nibbering, principal investigator, Department of Infectious Diseases

Telephone: +31(0)71 526 22 04