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Postdoc SUMO & the Ubiquitin-proteasome System

Would you like to be a postdoc on a TOP-project to study the role of SUMOylation in protein degradation? The LUMC offers a challenging research position in an exciting, international environment. Read on!

21 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Albinusdreef, Leiden, Zuid-Holland
Dienstverband:
Vast contract
Uren per week:
36 uur
Salarisindicatie:
€ 4481 per maand
Opleidingsniveau:
WO

Functieomschrijving

Our group is interested in the mechanisms and functional consequences of post-translational protein modification by SUMO and ubiquitin. We integrate biochemistry, cell biology and proteomics approaches and use state-of-the art microscopes and mass spectrometers to obtain novel insights in SUMO- and ubiquitin signal transduction. We have previously shown that SUMO-2/3 are able to form chains in an ubiquitin-like manner. These chains then cooperate with the ubiquitin-proteasome system to regulate target protein degradation. Furthermore, we have recently developed innovative methodology to study SUMOylation and crosstalk between SUMOylation and ubiquitin in a cell-wide manner. You will investigate crosstalk mechanisms between  post-translational protein modification by ubiquitin and SUMO (Small Ubiquitin-like Modifier) in cooperation with the group of Prof. Dr. Huib Ovaa in our department. You will study the important roles of SUMO and ubiquitin in protein degradation at a proteome-wide level and at the level of individual target proteins.

Functie-eisen

You have obtained a PhD degree in biomedical sciences or a similar field and have a strong background in protein purification, protein biochemistry, molecular biology and cell biology. Experience with ubiquitin-like proteins and protein degradation will be a distinct advantage, whereas experience in mass spectrometry is not required. You should be highly motivated, enthusiastic and creative as well as skilled and results-driven. Excellent written and oral communication skills are a must.

Conditions

You will be employed on the basis of 36 hours per week. Appointment is for three years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

Additional information

Contact

Prof. Dr. Alfred Vertegaal, Department of Cell and Chemical Biology, telephone +31 (0)71 526 96 21, email vertegaal@lumc.nl.

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