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Postdoc: Bimetallic Catalyst for Hyperpolarization Transfer

The aim of the postdoctoral research project is to develop and apply new hyperpolarisation tools for the NMR analysis of dilute components in complex …

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Comeniuslaan, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 uur
Salarisindicatie:
€ 4274 - € 4274 per maand
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

The aim of the postdoctoral research project is to develop and apply new hyperpolarisation tools for the NMR analysis of dilute components in complex mixtures. Key in this approach is the design and synthesis of a bimetallic construct, in which one metal ion (Ir) transfers the polarisation from para-hydrogen (p-H2) to the analyte, and the other provides weak alignment of the catalyst-analyte complex in the magnetic field of the NMR spectrometer.
An approach to increase the sensitivity of NMR is to induce non-Boltzmann nuclear spin state populations with hyperpolarisation techniques. Signal Amplication by Reversible Exchange (SABRE) is based on the reversible association of p-H2 and a substrate molecule to a mediating Ir complex in solution. The hyperpolarisation of p-H2 is transferred to nuclear spins of the substrate, maintained upon dissociation, and detectable, after transfer to high magnetic field, as strongly enhanced NMR signals.
High-field non-hydrogenative para-hydrogen-induced polarisation (HF-NH-PHIP) is designed to specifically detect the enhanced NMR signals of the substrate when transiently bound to the metal centre together with p-H2 in moderately slow exchanging SABRE complexes; it allows a straightforward implementation of signal averaging in combination with multidimensional NMR experiments. For substrates that interact only weakly with the metal centre, such as amino acids, carboxylic acids, ketones and aldehydes, the magnitude of the scalar coupling constants involved in the hyperpolarisation transfer (approx. 1 Hz or less) limits the applicability of SABRE. This is addressed by carrying out the hyperpolarisation transfer using residual dipolar couplings (RDCs) between hydrides and the nuclear spins of the substrate. This requires weak alignment of the Ir-complex in solution, which we propose to provide, in the high magnetic field of the spectrometer, by attaching a paramagnetic lanthanide group to the iridium catalyst via a rigid linker. For this purpose, the SABRE catalyst will be rigidly connected to a typical ligand for lanthanide ions, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). The distance between the lanthanide and iridium will be varied by inserting (rigid) aromatic rings.

Functie-eisen

  • you have a PhD in chemistry;
  • you have experience with synthesis and characterisation;
  • you have an interest in coordination chemistry and NMR;
  • you have an interest in supervising Bachelor’s and Master’s students in internships related to your research;
  • you are able to work in a multidisciplinary environment;
  • you are creative and want to work at the forefront of science;
  • you have excellent communication skills in spoken and written English;
  • you are a team player.

Conditions

  • employment: 1.0 FTE
  • a maximum gross monthly salary of € 4,274 based on a 38-hour working week (salary scale 10)
  • in addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus
  • duration of the contract: 3 years
  • classification in the Dutch university job-ranking system (UFO): Postdoctoral Researcher, Level 3
  • you will be able to make use of our Dual Career Service where our Dual Career Officer will assist with family related support, such as child care, and help your partner prepare for the local labour market and with finding an occupation

Are you interested in our excellent employment conditions?

Additional information

Dr. Martin C. Feiters, Associate Professor
Telefoon: +31 24 3652016
m.feiters@science.ru.nl

No commercial propositions please.