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Postdoctoral Researcher: Chromatin Biology Cellular Differentiation
This ambitious project will address the molecular epigenetic basis of cellular identity. The Polycomb group of proteins are important regulators of this identity as these proteins repress ectopic expression of developmental control genes. This controls ...
- Comeniuslaan, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 30 - 38 uur
- € 4084 per maand
This ambitious project will address the molecular epigenetic basis of cellular identity. The Polycomb group of proteins are important regulators of this identity as these proteins repress ectopic expression of developmental control genes. This controls proliferation, patterning and cell-lineage commitment and is deregulated in cancer. How Polycomb is targeted to genes in humans and other vertebrates has remained enigmatic for a long time, but our recent results have shed exciting new light on this issue: we have identified a protein that directs Polycomb to its target genes by direct binding of unmethylated DNA.
As a postdoctoral researcher you will further elucidate how Polycomb controls gene regulation. Using state-of-the-art molecular techniques (next-generation sequencing, mass spectrometry) you will examine how Polycomb recruitment is regulated during cellular differentiation and in malignancies. You will have the opportunity to develop and work on novel ideas.
- a PhD in molecular or cellular biology, molecular life sciences or a related field;
- experience in one or more of the following areas: molecular biology techniques, next-generation sequencing, genomics and gene regulation, or computational analysis;
- excellent communication skills in written and spoken English;
- strong analytical skills, a problem-solving and result-oriented attitude;
- the ability to work and interact with others in an energetic and supportive research environment.
Conditionsyou will be classified as a Postdoctoral Researcher 4 in the Dutch university job-ranking system (UFO).
The Faculty of Science is an equal opportunity employer, committed to building a culturally diverse intellectual community, and as such encourages applications from women and minorities.
Additional informationProf. dr. Gert Jan C. Veenstra
+31 24 3610541
molbio.science.ru.nl/about/molecular-developmental-biology/ ; veenstra.science.ru.nl/
Strategically located in Europe, Radboud University is one of the leading academic communities in the Netherlands. A place with a personal touch, where top-flight education and research take place on a beautiful green campus in modern buildings with state-of-art facilities.
Faculty of Science
We are looking for a highly motivated and ambitious experimental biologist to join our research team in the Department of Molecular Developmental Biology, located at the Radboud Institute for Molecular Life Sciences (RIMLS), Faculty of Science (Radboud University, Nijmegen, Netherlands). We offer a first class international research environment in regulation of gene expression and epigenetics using state-of-the-art genomic and proteomic technologies and bioinformatics. We run next-generation sequencers, single-cell equipment, and mass spectrometers, and we accommodate a bioinformatics team and a local computational infrastructure.
No commercial propositions please.