Atherosclerosis, the underlying cause of the majority of cardiovascular diseases, is a lipid-driven inflammatory disease of the large arteries. Experimental …
In this position we ask you to apply your bio-informatics skills and academic insights to offer practical solutions for the translation and application of complex ‘omics data in patient diagnostics.
- Landelijk / geen vaste standplaats
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 uur
In our laboratory, many different analytical techniques are applied in diagnostic screening for inborn errors of metabolism (IEM). However, with the introduction of high-resolution mass spectrometry instruments in clinical laboratories, we have aimed to innovate our diagnostic process by developing new holistic approaches. We have now established metabolomics- and glycomics-based analyses for IEM patient diagnostics. In these innovative diagnostic assays, challenges lie in the translation of big data to a clinically valuable result for an individual patient.
In this position we ask you to apply your bio-informatics skills and academic insights to offer practical solutions for the translation and application of complex ‘omics data in patient diagnostics. You will maintain and further optimize a data-analysis pipeline for plasma and cellular metabolomics, glycomics and glycoproteomics data from sample to final (diagnostic) report. This includes the design of pattern recognition algorithms to identify disease specific metabolic signatures in body fluids and establishment of software for analysis and interpretation of metabolic flux data from patient cells. You will guide a team of two statistical/chemometric experts and work in close collaboration with laboratory specialists and laboratory technicians who generate the data. In addition, you will work in close communication with bioinformaticians from the department of Human Genetics and laboratory information management system administrators. The project is situated in a challenging environment with sensitive patient data.
- Highly motivated and ability to work independently in an interdisciplinary environment at the cutting edge of science;
- Preferably a PhD or similar work experience in Bioinformatics related to Molecular Sciences;
- Level WO+;
- Preferably experience in laboratory bench work related to metabolomics;
- You are a team player with good communicational and leadership skills, able to work in a laboratory with international eminence;
- Experience with SQL, R or Matlab, and in one or more object-oriented programming languages (C#, VB.Net, C/C++, Java, etc.);
- Experience with Web development;
- Database development (MySQL);
- You recognise yourself in the Radboud way of working.
Scale 10: max. € 58838 gross income per year at full employment (incl. vacation bonus and end of year payments).
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG). Radboud university medical center’s HR Department will apply for this certificate on your behalf.
Read more about the Radboudumc employment conditions.
All additional information about the vacancy can be obtained from Dr. Karlien Coene, clinical chemist, Dr. Leo Kluijtmans, clinical biochemical geneticist or Prof. Alain van Gool, head Translational Metabolic Laboratory, +31 (0)24 361 45 67. Use the Apply button to submit your application.
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film.
Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboudumc is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.
The Radboudumc focuses on scientific health challenges of today, with an eye on emerging diseases of the future.
Read more about what it means to work at Radboudumc and how you can do your part.
The Translational Metabolic Laboratory
The experimental research for the project is housed in the Translational Metabolic Laboratory (TML), which is part of the Department of Laboratory Medicine. The laboratory is a mixed function laboratory with patient care and translational research. The laboratory houses the Radboud Technology Center Mass Spectrometry. TML harbors a range of top researchers in the areas of inherited (metabolic) diseases, disorders of movement, mitochondrial disease, protein glycosylation and more. Click here for more information about TML.