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  3. PhD candidate 'Bayesian modelling to develop N-of-1 trials for children with ASD''

PhD candidate 'Bayesian modelling to develop N-of-1 trials for children with ASD''

Current 'one-size fits- all' treatments for autism spectrum disorder (ASD) are unsuccessful in improving patient prognosis. Rational treatments are suggested …

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Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2422 - € 3103 per maand
Opleidingsniveau:
WO

Functieomschrijving

Current 'one-size fits- all' treatments for autism spectrum disorder (ASD) are unsuccessful in improving patient prognosis. Rational treatments are suggested but have not yet been tailored to the individual. This translational project incorporates predictive information from cutting-edge fundamental research using patient-derived stem cells 'brain-on-a-dish' in-silico models with innovative single patient trial (i.e. N-of-1 trial) methodology, with the ultimate goal to translate our findings to novel treatment implementations for children with ASD.

As a PhD candidate, your main tasks and responsibilities are:

  • Perform Bayesian network analysis of existing evidence from ASD trials in literature.
  • Perform Bayesian re-analysis of a successful recently completed randomized controlled trial in children with ASD testing a new treatment (bumetanide).
  • Develop the statistical protocol and methods for the aggregated N-of-1 trials design in the NewTDec consortium and analyse the trial data.
  • Co-write the aggregated N-of-1 trial manuscript and prepare for publication.

Functie-eisen

We are looking for highly motivated and enthusiastic researchers with:

  • A Master's degree in a field related to biomedical sciences and/or psychology.
  • Affinity for complex statistical analysis and/or Bayesian modelling related to neuroscience.
  • Interest in complex data analysis and pushing the boundaries of research through technology driven applications.
  • Experience with complex statistical models and biostatistics is a plus.
  • A flexible, pro-active team spirit but you can also work independently.
  • Excellent communications skills in English, both written and verbal.

Conditions

  • We offer a contract for 4 years after a trial period of 12 months.
  • Intending start date: 1 December 2019.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Additional information

If you are interested to join our research team, please apply and upload your CV and a letter describing your motivation, background and ambition to succeed in this project.

All additional information about the vacancy can be obtained from Dr. Hilgo Bruining, Department of Psychiatry, Amsterdam UMC or from Bas Stunnenberg MSc, Department of Neurology and Health Evidence, Radboudumc. Use the Apply button to submit your application.

Please apply before November 22, 2019.
Recruitment agencies are asked not to respond to this job posting.

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