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  3. PhD candidate 'Cross-resistance between endocrine treatment and radiotherapy in breast cancer'

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PhD candidate 'Cross-resistance between endocrine treatment and radiotherapy in breast cancer'

Patients with operable breast cancer are treated with surgery, and subsequently radiotherapy, endocrine and/or chemotherapy. Recent results from the …

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2422 - € 3103 per maand
Opleidingsniveau:
WO

Functieomschrijving

Patients with operable breast cancer are treated with surgery, and subsequently radiotherapy, endocrine and/or chemotherapy. Recent results from the Radiotherapy & OncoImmunology (ROI) laboratory indicate that prolonged anti-estrogen receptor treatment, leading to acquired endocrine treatment resistance, also induces radioresistance.

The current project will focus on preliminary results indicating that endocrine treatment of breast cancers induces particular immune pathways that may be involved in this cross-resistance. In the present project, the PhD candidate will investigate the activation of this pathway by estrogen receptor antagonists, and how this might subsequently induce radioresistance. Additionally, possible effects of endocrine treatment on anti-tumor immune responses will be assessed. Immunological/cell-biological approaches (FACS, Transfection/Crispr-CAS, Microscopy, colony forming assays) will be combined with murine xenografted tumor models, and analyses of available breast cancer patient cohorts.

Functie-eisen

The preferred candidate will have a MsC degree in biomedical sciences (molecular/cellular biology/medical biology). He/she has proven interest in pre-clinical research and a passion for science. Candidates with cell culture experience and/or holding an article 9 certificate for working with experimental animals are especially invited to apply.

Conditions

The employment for this position will start per January 1st, 2020.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

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Additional information

All additional information about the vacancy can be obtained from D r. Paul Span, department of Radiation Oncology, Radboudumc Nijmegen, Paul.Span@radboudumc.nl or via, +31 (0) 6 554 879 38. Use the Apply button to submit your application.

Please apply before September 23, 2019.
Recruitment agencies are asked not to respond to this job posting.