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PhD candidate for the SPHINCS project “Strategies to Prevent glomerular Hyperfiltration INjury in Congenital Solitary kidneys”

The current PhD research project is part of the Vidi grant from dr. Michiel Schreuder, entitled the SPHINCS project, which is aimed at unraveling the molecular mechanisms underlying renal hyperfiltration in solitary functioning kidneys.

20 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Landelijk / geen vaste standplaats
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Opleidingsniveau:
WO

Functieomschrijving

The current PhD research project is part of the Vidi grant from dr. Michiel Schreuder, entitled the SPHINCS project, which is aimed at unraveling the molecular mechanisms underlying renal hyperfiltration in solitary functioning kidneys.

Most individuals with a solitary functioning kidney start with a normal renal function, which is based on hyperfiltration. This compensation in function makes everything look alright, at least in the short-term. In the last decade, we have demonstrated that a congenital solitary functioning kidney leads to renal injury with hypertension and renal functional decline that may result in end-stage renal disease. About 50% of children born with a solitary functioning kidney develop hypertension by the age of 18 and up to 20-40% may require dialysis by the age of 30.

The mechanisms that lead to renal injury have only been partly unravelled, and knowledge on prognostic factors that distinguish between a good and an unfavourable prognosis are lacking. Therefore, it is difficult to counsel parents of a child with a solitary functioning kidney, and to individualize clinical monitoring. Knowledge on pathophysiological pathways is desperately needed to guide preventive and therapeutic strategies.

Highlights of this project are:

  • Evaluate postnatal uninephrectomy in rodents for the study of pathophysiological pathways. For this, both newborn rats, as well as knock-out mice will be used;
  • Test pharmacological intervention early in life in the animal models to prevent hyperfiltration and its associated renal injury;
  • Working in a multidisciplinary team;
  • Translation of basic research into novel diagnostic and therapeutic possibilities, which could lead to groundbreaking changes in the management of these kidney diseases.

Functie-eisen

  • Enthusiastic PhD candidate with a MSc in Molecular Life Sciences, Biology, Biomedical Sciences, or similar;
  • Your working style is well-structured and independent, but you are also a team player;
  • Your goal is to obtain your PhD degree, and in addition you have a strong ambition to become a successful scientist;
  • A permit to work with laboratory animals (art. 9) is a pre;
  • You recognise yourself in the Radboud way of working.

Conditions

Salary is € 2279 gross per month in the first year up to a maximum of € 2919 gross per month in the last fourth year, plus additional vacation bonus (8% per year) and end of year payments (8.3% per year)

Additional information

  • An employment contract for 1 year, with an extension of 3 years when performance is sufficient;
  • Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG). Radboud university medical center’s HR Department will apply for this certificate on your behalf;
  • Read more about the Radboudumc employment conditions.

We request applicants to send a motivation letter outlining their specific interest and qualifications regarding the position, their prior research/work experience, a CV, and contact information of two professional references.

Additional information about the vacancy can be obtained from Dr. Michiel Schreuder, Pediatric Nephrologist. Use the Apply button to submit your application.

Bedrijfsomschrijving

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film.

Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboudumc is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.

The Radboudumc focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Read more about what it means to work at Radboudumc and how you can do your part.

The department of Pediatric Nephrology combines top clinical care for children with renal diseases, including dialysis and transplantation, with translational research. The focus is on congenital anomalies of the kidney and urinary tract, and glomerular diseases such as complement mediated glomerular disease.