PhD candidate Genomics of tuberculosis susceptibility
This project will examine the mechanisms underlying innate resistance to Mycobacterium tuberculosis infection among heavily exposed tuberculosis (TB) contacts …
- Geert Grooteplein Zuid, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 - 36 uur
- € 2826 - € 4481 per maand
This project will examine the mechanisms underlying innate resistance to Mycobacterium tuberculosis infection among heavily exposed tuberculosis (TB) contacts in Indonesia. Each year, millions of people worldwide become infected with Mycobacterium tuberculosis. However, some people, even when heavily exposed to an infectious TB patient, do not get infected. They almost certainly inhale M. tuberculosis but contain or clear infection through innate immune mechanisms. We studied this phenomenon among heavily exposed household members of infectious TB patients in Indonesia. BCG vaccination exerted strong protection against M. tuberculosis infection, and those contacts who were protected had altered innate immune cell distributions and cytokine responses. This led to the hypothesis that BCG-induced 'trained innate immunity', mediated by epigenetic and metabolic reprogramming of innate immune cells, contributes to 'early clearance' of M. tuberculosis, and that trained immunity can be harnessed to help protect against M. tuberculosis infection.
You will work in a diverse and international group in TB research (head: Prof. Reinout van Crevel) and the large and internationally competitive research group of the laboratory of Experimental Internal Medicine at Radboudumc (head: Prof. Mihai Netea).
Tasks and responsibilities
- Genetic analysis (GWAS, QTL-analysis etc).
- Functional genomics analysis using multi-layer omics data.
- In-vitro experimental validation.
- Working in a diverse and competitive international research group.
- Contribution to capacity strengthening of partners in Indonesia.
- (Bio)medical or relevant/comparable MSc degree.
- Research or working experience in immunology/molecular biology ('wet-lab').
- Biostatistics, affinity for bio-informatics ('in-silico').
- Social skills, fun to work with.
- Fluency in English writing and communication.
- Employment preferably starts January 2020.
- The salary depends on education. Scale 10 will be offered to MSc medical graduates; those holding degrees in other disciplines will be offered scale 10A.
Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.
Additional informationAll additional information about the vacancy can be obtained from Reinout van Crevel, professor in Global Health and Infectious Diseases, Nijmegen, The Netherlands. Use the Apply button to submit your application.
Please apply before November 11, 2019.
Recruitment agencies are asked not to respond to this job posting.