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PhD candidate 'Improving treatment decisions in colorectal cancer – the role of tumor budding'

Do you want to improve diagnosis of colorectal cancer? Do you want to enable better treatment decisions for patients with colorectal cancer? Then you should join our team at the Radboudumc!

4 maanden geleden


Geert Grooteplein Zuid, Nijmegen, Gelderland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur


Do you want to improve diagnosis of colorectal cancer? Do you want to enable better treatment decisions for patients with colorectal cancer? Then you should join our team at the Radboudumc!

The Dutch Cancer Society (KWF) has awarded a consortium grant to our team for studying the potential of tumor budding (i.e. the presence of single tumor cells or small tumor clusters at the invasive front of cancer) as a biomarker. Together with international experts in the field of histological biomarkers in colorectal cancer we will develop a robust and reproducible method for quantification of tumor budding, validate the prognostic and predictive value of tumor budding, and determine the relationship with other biomarkers.

In this 4-year PhD-project, you will investigate the relationship between tumor budding and molecular subtypes. You will be involved in the collection of tumor samples and the associated clinical and follow-up data, and will perform histopathological and molecular analyses. Additionally, you will visit several of the other consortium partners doing on-site projects. You will work closely together with a PhD specialized in computational pathology and will be involved in digital image analyses. You will be part of a cross-disciplinary research team striving to do world-class science and answer many questions about colorectal cancer.


We are seeking a highly motivated candidate with (most of) the following qualifications:

  • Master's degree in Biomedical Sciences, (Medical) Biology, Medicine, or a relevant other discipline;
  • Interest in translational research in oncology and histopathology;
  • Experience with immunohistochemistry;
  • Affinity with analysis of large data sets using statistical software (e.g. SPSS);
  • Structured and accurate working style, demanding high quality of your own work;
  • Good English writing and presentation skills;
  • Strong self-motivation, flexibility, and persistence;
  • Well-developed skills to work in a multidisciplinary team;
  • You recognise yourself in the Radboud way of working.


Scale 10A: max € 40814 gross per year at full employment (incl. vacation bonus and end of year payments)

Read more about the Radboudumc employment conditions.

Additional information

All additional information about the vacancy can be obtained from Prof. Iris Nagtegaal, professor of Gastrointestinal Pathology. Use the Apply button to submit your application.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.


Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film.

Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboudumc is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.

The Radboudumc focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Read more about what it means to work at radboudumc and how you can do your part.

You will join a multidisciplinary team at the department of Pathology. The team is part of the Research Theme "Tumors of the Digestive Tract", one of the core themes of the Radboud university medical center. We will train and mentor you during the course of this project. You will join the PhD program of the Radboud Institute for Molecular Life Sciences (RIMLS).