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PhD candidate 'Molecular Therapies for Inherited Eye Diseases'

* Do not use the 'apply to job' button ** Stargardt disease (STGD1) is a progressive retinal disorder that initially affects central vision, and later can …

meer dan een jaar geleden


Geert Grooteplein Zuid, Nijmegen, Gelderland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
€ 2279 - € 2919 per maand


  • * Do not use the 'apply to job' button **
Stargardt disease (STGD1) is a progressive retinal disorder that initially affects central vision, and later can progress to a more severe visual impairment, often leading to complete blindness. STGD1 is caused by bi-allelic mutations in ABCA4, a gene that encodes a retina-specific transport protein. Yet, the exact mechanisms on how ABCA4 gene expression is regulated (i.e. transcriptional activation, pre-mRNA splicing) are not yet known, nor have all the genetic causes underlying STGD1 been completely unraveled. Finally, to date, no treatment is available to stop the progression or improve vision of many individuals with STGD1 worldwide.

A consortium of ten different groups from six different European countries have successfully applied for a Marie Sklodowska Curie Action Initial Training Network, coined StarT. This network allows us to hire fourteen PhD candidates to work on the various aspects of ABCA4 and STGD1 mentioned above. The position in my group will focus on developing novel splice modulation therapies for recurrent ABCA4 mutations underlying STGD1. The PhD candidate will be hosted within the Radboudumc, but, given the nature of the training network, receive a lot of training throughout the different participating institutes. In addition, candidates should perform a minimum of two secondments (weeks-to-months) within different partners lab, in order to maximize exchange and cooperation between the different groups.

As per ITN ruling, candidates that apply for a position within the Netherlands should not be Dutch, or have lived within the Netherlands for more than one year during the last three years.

Tasks and responsibilities
  • Plan and perform scientific in vitro and in vivo experiments in an independent manner;
  • Critically analyze data;
  • Take a leading role in writing manuscripts;
  • Present data at local, national and international scientific meetings;
  • Supervise MSc and/or BSc students.


Candidates must have completed a MSc degree in Molecular Life Sciences or a related field. They need to have a solid theoretical background in molecular and cell biology, as well as hands-on experience with standard molecular techniques such as PCR, cloning, RT-PCR, western blotting and cell culture. Experience with stem cell technology and/or molecular therapy is considered a strong plus.

Candidates should have a strong ambition to succeed in science, be result-oriented, and have strong communication skills (both orally and in writing). They should possess a critical scientific attitude and should be able to work both independently as well as in a team.


Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Additional information

The anticipated starting date is the 1st of March, 2019.

All additional information about the vacancy can be obtained from Dr. Rob Collin, associate professor Genetics, via +31 (024) 361 37 50. Use this Email address only for information.

Applications need to be submitted via the Euraxess application form, where candidates can indicate their preference for this, or any of the other 13 positions. Do not use the 'apply to job' button below.

This vacancy is open until filled.

Recruitment agencies are asked not to respond to this job posting.