PhD candidate 'Personalized treatment of thyroid diseases'
With a prevalence of 5-10%, thyroid diseases are among the most common diseases in the general population. Thyroid dysfunction, even mild, increases the risk …
- Geert Grooteplein Zuid, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 - 36 uur
- € 2357 - € 3020 per maand
With a prevalence of 5-10%, thyroid diseases are among the most common diseases in the general population. Thyroid dysfunction, even mild, increases the risk of various adverse clinical outcomes, including myocardial infarction, atrial fibrillation, stroke, depression and mortality. The current goal of treatment is normalization of the patient's serum thyroid parameters to levels within the population-based reference ranges. Despite having corrected thyroid hormone levels, ~15% of treated thyroid disease patients still have residual disabling hypo- or hyperthyroid complaints. Additionally, variation in thyroid function within the reference ranges is associated with cardiovascular disease and mortality. These are among the most important unresolved problems in endocrinology. All of this could be due to the fact that the thyroid parameters of the treated patient still deviate from their unique individual setpoint. Unfortunately, it is currently not possible to predict a patient's individual thyroid setpoint. However, we have recently identified many individual characteristics and (epi)genetic markers which are associated with serum thyroid parameters. The aim of this PhD project is therefore to start individualizing the treatment of patients with thyroid diseases.
- A master's degree in medicine or biomedical sciences;
- Strong affinity with statistics and preferably working with large datasets;
- Interest in translational research including various omics approaches (e.g., genomics, metabolomics);
- Strong leadership and organizational skills to effectively coordinate projects in a large consortium;
- Sufficiency in the Dutch language, fluency in written and spoken English.
ConditionsUpon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.
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Additional informationThe following should be included in your application: CV (including email address), list of followed courses (and grades if applicable), a letter of motivation, and reprints or, preferably, links to your Master thesis and scientific publications.
All additional information about the vacancy can be obtained from Dr. Marco Medici, internist-endocrinologist. Use the Apply button to submit your application.
Please apply before 1 March.
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