The goal of this PhD project is to critically improve interpretation of personal genome sequences using information on the sequences, structures and function of RNAs and proteins relevant for the cells or tissue of interest. The candidate will develop approaches to optimally use and integrate public and in-house full-length PacBio RNA sequencing data and bottom-up and top-down proteomics data. These approaches will be applied to a diverse set of medical conditions including immune, metabolic and intellectual disability disorders. By providing the atlases and software to the community and implementing the new algorithms into existing variant effect prediction software, this project will set the stage for wider use of transcriptome and proteome data in personalized medicine approaches.
You hold a Master of Science degree in Bioinformatics, hold a degree in Computer Science with proven knowledge of statistics and molecular biology or hold a degree in one of the biomedical sciences with proven programming skills. You must demonstrate a strong dedication to research and be interested in resolving important biomedical research questions with novel computational approaches. You have ample experience with programming languages like Python and R, as well as command line scripting languages. You work in a structured way, document your code and results and use version control systems (like Git). You are flexible and communicative, know how to explain your research to peers within and outside your field, enjoy working in a multidisciplinary team and you recognise yourself in the Radboud way of working.
Scale 10A: max € 40814 gross per year at full employment (incl. vacation bonus and end of year payments).
Read more about the Radboudumc employment conditions.
In your application letter, clearly indicate how your expertise and experience fits with the proposed project. The application procedure will consist of a first round of interviews and a presentation of one your research projects in a second stage.
All additional information about the vacancy can be obtained from Prof. Peter-Bram 't Hoen, professor of Bioinformatics and Head Centre for Molecular and Biomolecular Informatics. Use the Apply button to submit your application.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.