PhD candidate 'Vaccine Adjuvants triggering Antigen cross-presentation by DC'
In this project, a combination of immunological (Flow, functional assays), molecular (RNA seq, qPCR) and cell biological techniques (Microscopy) and read-outs are applied in pre-clinical mouse samples as well as human samples.
- Geert Grooteplein Zuid, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 uur
One key element in the induction of immune responses against tumors or pathogens is the ability of Dendritic Cells (DC) to cross-present antigens. Currently approved adjuvants induce robust antibody responses, but are weak in priming CD8+ killer cells (cell-mediated immunity), essential for cancer and pathogen clearance.
We recently uncovered part of the working mechanism of a new class of adjuvants that enforces T cell-mediated immunity and antibody responses via an unprecedented level of antigen cross-presentation by DC (den Brok et al Nature Communications 7, 2016). In a multi-disciplinary team also consisting of our industrial partner, the aim is to define the molecular signature associated with our cross-presentation inducing adjuvant in mouse and human DC. The overarching goal is to develop the next generation of this unique vaccine adjuvant for clinical applications.
In this project, a combination of immunological (Flow, functional assays), molecular (RNA seq, qPCR) and cell biological techniques (Microscopy) and read-outs are applied in pre-clinical mouse samples as well as human samples. In addition, animal experiments will be performed for vaccine efficacy studies.
- Masters degree in biomedical sciences at the interface of cell biology and immunology or equivalent and intrinsically motivated for scientific research and discovery;
- Experience/affinity with bioformatics tools is an advantage;
- You recognise yourself in the Radboud way of working.
Candidates with a background in cancer-immunology/biology holding an article 9 certificate for working with experimental animals and are especially invited to apply!
Scale 10A: max. € 40814 gross income per year at full employment (incl. vacation bonus and end of year payments)
All additional information about the vacancy can be obtained from Prof.dr. Gosse Adema, full professor via +31 (0)24 361 45 15. Use the Apply button to submit your application.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
Read more about the Radboudumc employment conditions.