Our research focuses on the elucidation of the molecular mechanisms underlying hormonal-mediated regulation of solute and water transport processes in epithelia including kidney and small intestine. The major emphasis is currently on the epithelial calcium (TRPV5 & TRPV6), magnesium (TRPM6 & TRPM7) and water (Aquaporin 2) channels, salt transporters (NCC, ENaC) and succinate receptors that constitute instrumental solute transport pathways in epithelia. The current projects aim to investigate in detail the regulation of these transport activities in health and disease. To this end, a wide variety of cutting edge techniques will be applied including cell and molecular biological, genetics biochemical and physiological procedures.
Tasks and responsibilities:
- The PhD student will design and perform scientific research in the area of molecular transport physiology in health and disease
- Generates and analyses the data in order to contribute to scientific publications and presents findings at scientific meetings
- Works in a team with other students and scientists to discuss, plans and performs research in a stimulating environment
- Works in a highly international research group with fellows from many countries
- Completes the project with a scientific dissertation
Information about the vacancy can be obtained from Prof. Joost Hoenderop, +31 (0) 24-3610580, firstname.lastname@example.org, (use this email address only for information, for application use the apply button).
Detailed information about the department can also be found at http://www.physiomics.eu and on You Tube.
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The department of Physiology provides an international and stimulating working environment for its 50 employees and is an exciting place to perform basic research, translational and clinical medicine, and enjoy teaching. The department encompasses complementary research groups whose interests range from cardiovascular adaptations to inactivity, molecular regulation of ion transport processes in the kidney to the study of osmoregulation in the body. Working collaboratively within the department, we use our expertise to investigate how molecules, cells, organisms and humans function and how we might modulate their physiology to ultimately improve health in the patient.
The department consists of the research groups Integrative Physiology, Ion Transport and Osmoregulation and is part of the Nijmegen Centre for Molecular Life Sciences (NCMLS), a leading multidisciplinary graduate school within the domain of molecular mechanisms of disease and particularly in the fields of molecular medicine, cell biology and translational research.