Ongeveer 15 uur geleden - VU - Amsterdam
The Vrije Universiteit Amsterdam School of Business and Economics established the Hermine Weijland Fellowship in 2017 with the aim of attracting and promoting …
The field of genetic disorders has been revolutionized in recent years through the advent of next-generation sequencing technologies. Functional assessment of the many identified genetic variants has traditionally been performed via dedicated diagnostic assays.
The field of genetic disorders has been revolutionized in recent years through the advent of next-generation sequencing technologies. Functional assessment of the many identified genetic variants has traditionally been performed via dedicated diagnostic assays. Progress in high-resolution mass spectrometry have enabled more holistic approaches for metabolite profiling in body fluids and cells. The current project involves the establishment and application of cellular metabolomics for flux analysis. The goal is to provide a dynamic image of entire metabolic pathways to assess the functional consequences of mutations in genetic disorders of glycosylation and mitochondrial metabolism. In the longer run, this approach will be applied to additional genetic disorders, including known and newly identified gene defects.
The project is embedded in a large innovation project within the Translational Metabolic Laboratory (TML) of the Radboudumc to establish functional –omics methodologies based on mass spectrometry for disease gene identification and confirmation. The applicant will interact closely with bio-informaticians, mass spectrometry specialists, and staff and technicians specialized in various genetic disease groups.
The postdoc will establish and apply cellular metabolomics methodologies for flux analysis. You will be involved in the design and validation of existing and novel methods, with the goal to cover in first instance sugar metabolism and central carbon metabolism, with later extension to additional metabolic pathways. Additionally, you will support mass spectrometry developments in the metabolomics group, and will contribute to the evaluation of different approaches to extract high quality and clinically relevant information together with a post-doc bio-informatics and collaborate with a post-doc functional genomics to definitely confirm the functional consequences of genetic mutations.
Tasks and responsibilities
Scale 10: max. € 58838 gross income per year at full employment (incl. vacation bonus and end of year payments).
Read more about the Radboudumc employment conditions.
Applications should send a letter of intent outlining their specific interest in the position, overall related qualifications, experience and career goals, a curriculum vitae and details of professional references.
All additional information about the vacancy can be obtained from Dr. Dirk Lefeber, associate professor Glycosylation Disorders and Dr. Richard Rodenburg, Clinical Laboratory Geneticist Mitochondrial Medicine, who can be contacted through the TML secretary office via +31 (0)24 3614567. Use the Apply button to submit your application.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.