Ongeveer 24 uur geleden - Technische Universiteit Eindhoven - Eindhoven
Postdoc 'Augmentation of NK cell therapy in ovarian cancer through mRNA-mediated cytokine expression'
Augmentation of NK cell therapy in ovarian cancer through mRNA-mediated cytokine expression.Ovarian cancer is the most lethal malignancy in women and novel …
- Geert Grooteplein Zuid, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 - 36 uur
- € 2750 - € 4361 per maand
FunctieomschrijvingAugmentation of NK cell therapy in ovarian cancer through mRNA-mediated cytokine expression.
Ovarian cancer is the most lethal malignancy in women and novel treatment modalities are urgently needed. Intraperitoneal infusion of natural killer (NK) cells is being explored as a cell-based immunotherapy. However, currently optimal stimulation of activity is hampered by the limited availability of cytokines. In this project, we therefore aim to provide co-stimulatory cytokines through transient expression achieved by intraperitoneal delivery of mRNA nanomedicines and assess the impact of this expression on tumor cell clearance in mouse models of ovarian cancer.
This project is funded by the Dutch Cancer Foundation and is a joint activity of the Departments of Biochemistry, Laboratory Hematology and Gynaecology of the Radboud University Medical Center in collaboration with one of the world-leading providers.
We are searching for a highly motivated candidate with experience in gene delivery and detection of expression, fluorescence microscopy and animal experimentation using tumor models. We offer a cutting-edge research project at the interface of nanomedicine and immunotherapy and a highly stimulating, interdisciplinary research environment with state-of-the-art research facilities.
ConditionsStarting date as soon as possible and before 01 May 2019. The contract will first be limited to 6 months with extention to 15 months upon first demonstration of feasibility.
Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.
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Additional informationAll additional information about the vacancy can be obtained from Prof. Dr. Roland Brock, Departement of Biochemistry or Dr. Harry Dolstra, Laboratory Hematology. Use the Apply button to submit your application.
Please apply before 20 February.
Recruitment agencies are asked not to respond to this job posting.