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  3. Postdoc Genomics of tuberculosis susceptibility

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Postdoc Genomics of tuberculosis susceptibility

This project will examine the mechanisms underlying innate resistance to Mycobacterium tuberculosis infection among heavily exposed tuberculosis (TB) contacts …

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Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2826 - € 4481 per maand
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

This project will examine the mechanisms underlying innate resistance to Mycobacterium tuberculosis infection among heavily exposed tuberculosis (TB) contacts in Indonesia. Each year, millions of people worldwide become infected with Mycobacterium tuberculosis. However, some people, even when heavily exposed to an infectious TB patient, do not get infected. They almost certainly inhale M. tuberculosis but contain or clear infection through innate immune mechanisms. We studied this phenomenon among heavily exposed household members of infectious TB patients in Indonesia. BCG vaccination exerted strong protection against M. tuberculosis infection, and those contacts who were protected had altered innate immune cell distributions and cytokine responses. This led to the hypothesis that BCG-induced 'trained innate immunity', mediated by epigenetic and metabolic reprogramming of innate immune cells, contributes to 'early clearance' of M. tuberculosis, and that trained immunity can be harnessed to help protect against M. tuberculosis infection.

You will work in a diverse and international group in TB research (head: Prof. Reinout van Crevel) and the large and internationally competitive research group of the laboratory of Experimental Internal Medicine at Radboudumc (head: Prof. Mihai Netea).

Tasks and responsibilities

  • Genetic analysis (GWAS, QTL-analysis etc).
  • Functional genomics analysis using multi-layer omics data.
  • In-vitro experimental validation.
  • Working in a diverse and competitive international research group.
  • Contribution to capacity strengthening of partners in Indonesia.

Functie-eisen

  • (Bio)medical or relevant/comparable PhD degree.
  • Research or working experience in immunology/molecular biology ('wet-lab').
  • Biostatistics, affinity for bio-informatics ('in-silico').
  • Social skills, fun to work with.
  • Fluency in English writing and communication.

Conditions

Employment preferably starts January 2020.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Additional information

All additional information about the vacancy can be obtained from Reinout van Crevel, professor in Global Health and Infectious Diseases, Nijmegen, The Netherlands. Use the Apply button to submit your application.

Please apply before November 11, 2019.
Recruitment agencies are asked not to respond to this job posting.