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Postdoc ‘How does CNNM2 regulate magnesium transport in the kidney?’

Mutations in CNNM2 membrane proteins were identified to be causative for hypomagnesemia, intellectual disability and seizures. CNNM2 mutations among the most …

12 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 3403 - € 3403 per maand
Opleidingsniveau:
WO

Functieomschrijving

Mutations in CNNM2 membrane proteins were identified to be causative for hypomagnesemia, intellectual disability and seizures. CNNM2 mutations among the most common genetic causes for rare dominant hypomagnesemia. Currently, there are no clinical protocols for the diagnosis and follow-up of patients with CNNM2 mutations. Although it has been described that CNNM2 mutations impair renal magnesium reabsorption, the mechanisms that explain the disease are poorly understood.

Improving diagnostics and treatment can only be reached by systematic phenotyping of all known patients and by better understanding of the function of the CNNM2 protein. Based on our previous and preliminary data, we hypothesize that the function of CNNM2 is dependent on its interaction partners. Elucidation of the structure, regulation and function of the full CNNM2-complex will therefore aid to understand the pathogenesis of CNNM2 disease.

In this project, we aim to improve the understanding of CNNM2-associated disease by integrated structural, functional and biochemical techniques. The project is part of the large interdisciplinary FIGHT-CNNM2 research consortium. The postdoctoral fellow will work in close collaboration with research partners from Spain, Germany and Canada, the European Reference Network ERKNet and the patient association HIPOFAM. Altogether this innovative and international multidisciplinary network combines expertise in biochemistry, molecular and cell biology, genetics, structural biology, bioinformatics and patient care.

Tasks and responsibilities

  • Design and perform scientific research in the area of molecular biology, biochemistry and physiology.
  • Generates and analyses the data in order to contribute to scientific publications and presents findings at scientific meetings.
  • Works in a team with other students and scientists to discuss, plans and performs research in a stimulating environment.

Functie-eisen

  • PhD degree in Biomedical Sciences
  • Independent and well-structured working style
  • Strong motivation to succeed in scientific research
  • Well-developed social skills directed to work in a team
  • Preferentially experience with animal experimentation (art. 9)

Conditions

The position is initially for 12 months, with a possible extension to 3 years.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Additional information

An assessment can be part of the selection procedure.

Application
Applicants should send a letter of intent outlining special interest in the position, overall related qualifications, experience and career goals, a curriculum vitae and names and addresses of professional references.

Information
All additional information about the vacancy can be obtained from Dr. Jeroen de Baaij, Assistant Professor via +31 (0) 24 361 73 47 or from Prof. Joost Hoenderop, Full Professor of Molecular Kidney Physiology via +31 (0) 24 361 05 80. Use the Apply button to submit your application.

Please apply before 28 May 2020.
Recruitment agencies are asked not to respond to this job posting.

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