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Postdoc 'Modeling autism spectrum disorders using iPSC derived neuronal models'

We are offering two SFARI-funded postdoc positions for a fixed term of 3 years to perform research on modeling autism spectrum disorders using iPSC derived …

4 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Opleidingsniveau:
WO

Functieomschrijving

We are offering two SFARI-funded postdoc positions for a fixed term of 3 years to perform research on modeling autism spectrum disorders using iPSC derived neuronal models in 2D.

The projects will capitalize on a hiPSC phenotyping platform that we have established and which is based on the differentiation of patient-derived neurons on micro-electrode arrays (MEAs), to interrogate the functional consequences of ASD-linked variants at the level of E/I balance (Frega et al., 2019; Gunnewiek et al., 2020; Linda et al., 2020; Mossink et al., 2021a). You will combine network measurements with transcriptomic data (single nuclei transcriptomics) in the same experiment to identify molecular mechanisms underlying specific network phenotypes. You will model a large representative panel of 18 rare ASD variants, validate variants of unknown significance (VUS) and develop/test genetic rescue strategies.

The research will be located at the Human genetics Department (Nadif Kasri group) and embedded in the Donders Institute for Brain, Cognition and Behaviour of the Radboud University Medical Center.

Our research team at the Radboud university medical center is renowned for its genetic, molecular and electrophysiological research in the field of neurological and neurodevelopmental disorders. Over the past years we have developed unique knowledge and resources, such as the human (patient) induced pluripotent stem cell lines, including the required experimental platforms for in-detail assessment of the derived human neuronal in-vitro

Tasks and responsibilities
  • You will be responsible for the functional characterisation of IPSC-derived neuronal networks from ASD patients.
  • Design and perform scientific research.
  • You will be responsible for developing novel therapeutical strategies for selected ASD cases.
  • Work in a team with PhD students, scientists and clinicians.
  • You will be responsible for integrating electrophysiology data with transcriptomics data (MEA-seq).
  • Discus, plan and perform research in a stimulating environment
  • Work in a highly international research group and is willing to travel to other institutes within Europe.

Functie-eisen

Postdoc position 1:
  • Phd in molecular life sciences, biomedical sciences or a related discipline.
  • A strong background in molecular and cellular neuroscience.
  • Experience in experience in single cell (patch clamp) and /or network electrophysiology (MEAs).
  • Experience with cell culture of primary neurons and induced pluripotent stem cells.
Postdoc position 2:
  • Phd in molecular life sciences, biomedical sciences or a related discipline.
  • A strong background in bioinformatics.
  • Experience with analysing transcriptomics data and data integration.

Conditions

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.

Additional information

All additional information about the vacancy can be obtained from Dr. N. Nadif Kasri, assistant professor Human Genetics. Use the Apply button to submit your application.