1 dag geleden - Universiteit van Amsterdam (UvA) - Amsterdam
The Amsterdam School for Cultural Analysis (ASCA), one of the six research schools of the Faculty of Humanities, currently has a vacant postdoctoral position …
This post is available for a fixed term of 3 years (postdoc) or 4 years (PhD candidate) to perform research in relation to Dravet syndrome, also known as severe myoclonic epilepsy of infancy
This post is available for a fixed term of 3 years (postdoc) or 4 years (PhD) to perform research in relation to Dravet syndrome, also known as severe myoclonic epilepsy of infancy. The research will be based at the Human Genetics department of the Radboud university medical center in close collaboration with the Academic Centre for Epilepsy (ACE) Kempenhaeghe and Maastricht University Medical Center. The aim is to develop an epilepsy ‘brain-on-a-chip’ model that captures the genetic and phenotypic heterogeneity found in Dravet syndrome making use of induced pluripotent stem cells. This brain-on-chip model will be developed as a predictive in vitro platform that can be used for personalized medicine.
Our research group at the Radboudumc is renowned for its genetic research in the field of neurodevelopmental disorders. Over the past years we have developed unique knowledge and resources, such human (patient) cell lines, including induced pluripotent stem cells to generate neurons. Here we propose to exploit our knowledge and resources to develop new strategies for intervention in Dravet syndrome in a two tier approach. First, we will model Dravet syndrome by differentiating hIPSCs to neurons on micro-electrode arrays and measure their neuronal network activity, using well-established neurophysiological parameters (synaptic activity, network activity) as readout. Second, we will perform a pharmaceutical screen based on retrospective data available through ACE Kempenhaeghe.
Tasks and responsibilities
This position is funded by a ‘ZonMW Topsubisdie’. The position is designed and funded as a 3-4 year full-time position. Intended starting date is July 2018;
Salary is € 4216 (Postdoc)/ € 2279 (PhD) gross per month in the first year, plus additional vacation bonus (8% per year) and end of year payments (8.3% per year);
Read more about the Radboudumc employment conditions.
Conditions of employment
Applicants should send a letter of intent outlining special interest in the position, overall related qualifications, experience and career goals, a curriculum vitae and names and addresses of two professional references.
All additional information about the vacancy can be obtained from dr. Nael Nadif Kasri, assistant Professor Donders Institute of Brain, Cognition and Behaviour and the Department of Cognitive Neurosciences, Department of Human Genetics or from dr. Hans van Bokhoven, full professor Department of Human Genetics. Use the Apply button to submit your application.