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Postdoc ‘Pediatric intestinal drug transport’

The aim of this project is to specifically look at the intestinal absorption of drugs and drug-like molecules, as most drugs given to children are delivered by oral administration.

6 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

Children are not small adults. Adult drug doses cannot be extrapolated to children by simply adjusting for weight or size. Due to growth and development, the processes that determine how drugs are handled by the human body undergo important changes. If drugs are dosed solely based on adult doses, they may not work or reach toxic concentrations. With a better understanding on how drugs are handled in children of different ages, we can provide more effective and safe drug therapies to the pediatric population.

The aim of this project is to specifically look at the intestinal absorption of drugs and drug-like molecules, as most drugs given to children are delivered by oral administration. Drug transporters and metabolizing enzymes in the intestinal wall largely determine how fast and how much of a drug will reach the systemic circulation. To date, our knowledge on these transporters and metabolizing enzymes in children is very limited. We do not know how their activity changes from birth to adolescence. Hence, it is difficult to predict doses of orally administered drugs.

In this project we will study the maturation of transporters and drug metabolizing enzymes, important for drug absorption, in intestinal tissues from children. This project is challenging as it requires collection of left-over tissue from pediatric surgeries and aims to set-up an ex vivo technique to measure drug absorption in these tissues.

Functie-eisen

We are looking for a creative and enthusiastic researcher with a Ph.D. degree in Biomedical Sciences, Pharmacy, Pharmaceutical Sciences, Medicine or similar, with a clear interest in ex vivo experimental studies and pharmacology. Proven laboratory skills, preferably with excellent fine motor skills, as well as good communication skills are mandatory. Experience with Pediatric Pharmacology is a pre. The candidate needs to be willing and able to work during evening/night hours to collect pediatric tissue from the OR and perform ex vivo experiments with ad hoc available pediatric tissue. Finally, you should recognize yourself in the Radboud way of working.

Conditions

Scale 10: max. € 58838 gross income per year at full employment (incl. vacation bonus and end of year payments)

Additional information

Application
Applicants should send a letter of intent (in pdf) outlining special interest in the position, a CV, list of followed courses and grades, letter of motivation and preferably a reprint of the PhD thesis or any publications in English you have written.

Information
Additional information about the vacancy can be obtained from Prof. Saskia de Wildt, full professor of Clinical Pharmacology. Use the Apply button to submit your application.

First job interview will take place on: 28 or 29 May 2018.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions.