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Postdoc 'Protein Nanocarriers for Anticancer Therapy'

A postdoctoral position is available for the development of temperature‐responsive polypeptide nanocarriers for controlled drug delivery to metastasized ovarian cancer. The function is part of the European project TEMPEAT.

3 months

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 uur
Opleidingsniveau:
Postdoctoraal

Functieomschrijving

A postdoctoral position is available for the development of temperature‐responsive polypeptide nanocarriers for controlled drug delivery to metastasized ovarian cancer. The function is part of the European project TEMPEAT. The nanocarrier systems will be made and tested in close collaboration between TU/e and the Radboudumc. Activities include the synthesis and characterization of nanoparticles, their functionalization, optimization and functional characterization, in vitro and in vivo. The techniques range from protein expression and purification to the characterization of nanoparticles using physicochemical techniques, cellular uptake and activity to in vivo testing in murine ovarian cancer models. The research tasks are closely embedded in ongoing research activities of the participating departments. As a post-doc you will be responsible for the overall organization of the project at TU/e and Radboudumc, and it is expected that you will be working at both sites.

The research of the Bio-organic chemistry group is aimed at the development of smart nanosized compartments. These compartments are used in nanomedicine as vehicles in drug delivery and as scaffolds in immunology. Furthermore, they are employed as nanoreactors, with application potential in artificial cell and organelle research. The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.

Functie-eisen

We seek a highly talented, enthusiastic, and exceptionally motivated postdoc candidate with experience in at least two of the following fields: Protein engineering, nanomedicine, cell biology, advanced microscopy. Experience with animal experimentation (level 9 course) is strongly desired. At the beginning, the focus of the activities will be in Eindhoven, with a gradual shift to Nijmegen at the Depts. of Gynecology and Biochemistry.

The candidate must have strong communication and organizational skills. Fluency in written and spoken English is obligatory. The candidate should be able to work in a team and be willing to function in two institutes. And you recognise yourself in the Radboud way of working.

Conditions

  • A challenging job interfacing the research groups of bio-organic chemistry, TU/e, Eindhoven, and the Depts. of Biochemistry and Gynecology, of the Radboud University Medical Center, both in The Netherlands;
  • A full-time split appointment by Eindhoven University of Technology (50%) and Radboudumc (50%) for a period of 1 year. After a good evaluation your contract can be extended with an additional period of max. 2 years;
  • The gross monthly salary (scale 10) depends on your experience and is in accordance with the Collective Labor Agreement of the Dutch Universities (TU/e) and Collective Labor Agreement University Medical Center (Radboudumc);
  • An attractive package of fringe benefits, including excellent work facilities, childcare, moving expenses, sports facilities, an extra holiday allowance (8%, May), and an end-of-year bonus (8.3%, December).
  • Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.
  • Read more about the Radboudumc employment conditions.

Additional information

Application
Your application should be addressed to Prof.dr.ir. Jan van Hest, Prof.dr. Roland Brock and Dr. William Leenders. Your application must include: a one-page personal motivation letter, a digital copy of your PhD thesis, a CV including the names and contact details of two recent references. Only complete applications will be considered.

Information
For more information you can contact:


This vacancy is open until filled.

Bedrijfsomschrijving

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film.

Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboudumc is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.

The Radboudumc focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Read more about what it means to work at radboudumc and how you can do your part.

Eindhoven University of Technology (TU/e)
The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About the Department of Biomedical Engineering (BME)
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film. Read more about what it means to work at Radboudumc and how you can do your part.

The Radboud Institute for Molecular Life Sciences (RIMLS) at the Radboudumc conducts research on the molecular basis of health and disease with the aim to develop new diagnostics and therapies. Nanomedicine and Women’s cancers are two of the research themes of the Radboudumc. The Radboudumc provides excellent research facilities among which the microscopy imaging center with a panel of advanced microscopy techniques, the PRIME for preclinical imaging, and facilities for animal experimentation.

Departments of Biochemistry and Gynecology:
The Department of Biochemistry is one of the preclinical departments of the Radboudumc with research in targeted drug delivery, regenerative medicine and tissue engineering, and mitochondrial dynamics and metabolism. Fundamental research is conducted in close collaboration with clinical groups to promote a translation of fundamental insights into potential clinical applications. TEMPEAT builds on projects using protein engineering of nanobodies to target cancer and intracellular delivery of nanoparticles using cell-penetrating peptides.

The Department of Biochemistry has a long-standing collaboration with the Department of Gynecology and in particular Gynecological Oncology which provides patient care in this field but also strives to develop novel treatment regimes with the aim to improve the survival and quality of life of the patients.