Postdoc ‘Single-cell RNA sequencing to unravel renal physiology and pathophysiology’
The kidney is a complex organ that consists of many different cell types, each with different functions and specific expression patterns. In many kidney …
- Geert Grooteplein Zuid, Nijmegen, Gelderland
- Tijdelijk contract / Tijdelijke opdracht
- Uren per week:
- 36 - 36 uur
- € 3403 - € 3403 per maand
The kidney is a complex organ that consists of many different cell types, each with different functions and specific expression patterns. In many kidney diseases, specific renal cells undergo major transcriptional changes that drive the disease progression. However, research on these transcriptional changes in renal disease has been challenging, as modifications in sub-populations of renal epithelial cells do not necessarily translate in changes at the whole-organ level.
By the rapid revolution of next-generation sequencing techniques, it has become possible to perform reliable and quantitative single-cell RNA-sequencing. As a result, transcriptional regulation at the level an individual cell level can be measured to detect changes in renal cell populations and to identify new cell types. Single-cell studies are shown to be of clinical interest, predicting the outcome of an infection or drug resistance. Single-cell RNA-sequencing is set to change our understanding of kidney disease, since the heterogeneity inside the kidney can now be described with unprecedented resolution.
This project aims to identify the transcriptional mechanisms that cause disturbances in electrolyte transport and renal cyst formation using single-cell RNA sequencing and state-of-the-art bioinformatic data-integration.
Tasks and responsibilities
- Design and perform scientific research in the area of molecular biology, cell biology and bioinformatics.
- Generates and analyses the data in order to contribute to scientific publications and presents findings at scientific meetings.
- Works in a team with other students and scientists to discuss, plans and performs research in a stimulating environment.
- PhD degree in Biomedical Sciences.
- Independent and well-structured working style.
- Strong motivation to succeed in scientific research.
- Well-developed social skills directed to work in a team.
- Preferentially experience with bioinformatics and big data analysis.
ConditionsUpon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.
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Additional informationAn assessment can be part of the selection procedure.
Applicants should send a letter of intent outlining special interest in the position, overall related qualifications, experience and career goals, a curriculum vitae and names and addresses of professional references.
All additional information about the vacancy can be obtained from Dr. Jeroen de Baaij, Assistant Professor via +31 (0) 24 361 73 47. Use the Apply button to submit your application.
Please apply before 28 May 2020.
Recruitment agencies are asked not to respond to this job posting.
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