The Huynen group at the Centre for Molecular and Biomolecular Informatics (CMBI) offers a 2-year postdoc for research in system vaccinology of Bordetella pertussis. Bordetella pertussis infection levels and mortality levels are rising, necessitating research into new tools to assess the efficacy of new vaccines. Within the European Periscope project, which is funded by Innovative Medicines Initiative (IMI) and the Bill and Melinda Gates foundation, we collect molecular (RNAseq), cellular (Eurflow) and immunological data from multiple clinical trials to measure the response to vaccination and infection.
The candidate has a strong bio-computational background and will do comparative analyses of these data in order to detect which short term molecular and cellular observables correlate with various immunological parameters like antibody levels and T-cell responses. That we have data from multiple, parallel trials, allows comparative analyses between them and with data from model species to derive robust models. Furthermore, the multidimensionality of the data allows e.g. de-convolution approaches to delineate the gene expression per cell type and detect the genes whose expression reflects a successful vaccination.
The candidate will take a leading role in such comparative analyses and in their immunological interpretation and will communicate the results within the CMBI and with the Periscope consortium.
We are looking for a PhD in systems biology and/or bioinformatics and proven research interest into molecular biology with a background in immunology.
Scale 10: max € 58838 gross per year at full employment (incl. vacation bonus and end of year payments)
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Center for Biomolecular and Molecular Informatics (CMBI)
The CMBI is a bioinformatics centre that has a long experience in the comparative analysis of ‘omics data to obtain biological insights and prioritize experimental follow up. We offer a lively, international environment driven by curiosity and high quality science.