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  3. Postdoc 'Understanding cGAS activation to improve Immuno-radiotherapy combinations'

Postdoc 'Understanding cGAS activation to improve Immuno-radiotherapy combinations'

The cGAS/Sting pathway links radiotherapy to immune activation. Potent immune response induction, however, requires immunogenic cell death and triggering of …

28 dagen geleden

Arbeidsvoorwaarden

Standplaats:
Geert Grooteplein Zuid, Nijmegen, Gelderland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
36 - 36 uur
Salarisindicatie:
€ 2826 - € 4481 per maand
Opleidingsniveau:
WO

Functieomschrijving

The cGAS/Sting pathway links radiotherapy to immune activation. Potent immune response induction, however, requires immunogenic cell death and triggering of multiple immune activation pathways simultaneously. Aim of this project is to understand cGAS activation and function, to study immune pathways synergizing with cGAS and to define Radiotherapy regimens optimal for Immuno-radiotherapy combinations.

Immunological/Cell-biological approaches (FACS/functional assays, Transfection/ Crispr/CAS, Microscopy) will be combined with syngeneic tumor models and state of the art immunology technologies. Findings will be extrapolated to human blood and tissue samples.

Functie-eisen

The preferred postdoc candidate will have a PhD degree in biomedical sciences (biology/immunology) or equivalent, proven interest in pre-clinical research and a passion for science.

Candidates holding an article 9 certificate for working with experimental animals and with experience in molecular and functional Immunology are especially invited to apply.

Conditions

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Additional information

All additional information about the vacancy can be obtained from Prof. Gosse Adema, full professor via +31(24) 361 45 15. Use the Apply button to submit your application.

Please apply before December, 17.
Recruitment agencies are asked not to respond to this job posting.

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