Ongeveer 13 uur geleden - Technische Universiteit Eindhoven (TU/e) - Eindhoven
The project is aimed at developing multiscale models to accurately describe specific adsorption processes of industrial interest. It will be performed in close…
Biological nanopores are an exciting new class of biosensors, which main practical application is in single-molecule sequencing and single-molecule analysis. We are looking for talented and motivated students that are willing to engage in a ...
Biological nanopores are an exciting new class of biosensors, which main practical application is in single-molecule sequencing and single-molecule analysis. We are looking for talented and motivated students that are willing to engage in a PhD program in any of the following subjects:
DE NOVO DESIGN OF NANOPORES. In collaboration with the Molecular Dynamics Group at the University of Groningen the candidate will use molecular dynamic simulations in combination with advanced chemical and biochemical techniques to design nanopores with targeted diameter, shape and function.
PROTEIN SEQUENCING. As part of a consortium that includes researchers from Delft and Wageningen, the candidate will develop, engineer and re-design biological nanopores that will allow the sequence identifications of proteins as they are translocated across a nanopore. This will be the first technology that will be able to identify and sequence proteins at the single-molecule level.
SINGLE-MOLECULE ENZYMOLOGY. Small enzymes will be immobilized inside a biological nanopore either genetically, via Disulfide Bridge, by click chemistry or by non-covalent interactions. The conformational changes associated with catalysis will then be observed by the altered ionic flow through the nanopore.
The candidate should hold a Masters Degree in Chemistry, Chemical Biology, Biochemistry or Biotechnology or equivalent.
Expertise in molecular biology (recombinant DNA techniques, protein expression and purification), chemical modification of proteins or peptides, MD simulations will be an advantage, but is not a limiting factor.
Faculty of Mathematics and Natural Sciences
Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 30,000 students and researchers to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.
Two PhD positions investigating the physical and chemical properties of nanopores are available in the laboratory of Prof. Giovanni Maglia in the department of Chemistry and Biotechnology of the University of Groningen, the Netherlands.
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