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  3. PhD Biophysics Eukaryotic Replication

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PhD Biophysics Eukaryotic Replication

In recent years, it has become possible to reconstitute the activity of eukaryotic replisome in biochemical experiments, including on chromatin substrates. …

bijna 4 jaar geleden


Van der Maasweg, Delft, Zuid-Holland
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
€ 2266 - € 2897 per maand


In recent years, it has become possible to reconstitute the activity of eukaryotic replisome in biochemical experiments, including on chromatin substrates. Here, you will take on the exciting challenge of understanding the dynamics of chromatin replication by studying this key biological process at the single-molecule level. This includes examining the advance of the replisome in the face of nucleosomes, and the transfer and loading of nucleosomes onto the daughter strands by histone chaperones, among other topics. To do this, you will utilise our high-throughput fluorescence imaging and single-molecule force spectroscopy systems that are capable of acquiring large datasets under a variety of different conditions. You will be involved in the purification and labelling of proteins as necessary. You will analyse resulting datasets using biophysical modelling, and discuss extensively with collaborators in the Diffley Lab (Francis Crick institute) in the areas of molecular biology and biochemistry.   


We are looking to hire outstanding experimentalists for this exciting ERC-funded collaborative project at the interface of biochemistry and biophysics. We are looking for several prospective PhD students and post-doctoral researchers keen to participate in different aspects of this project that is aimed at understanding the mechanistic aspects of chromatin replication. As a researcher on this project, you will be responsible for planning and carrying out experiments and for analysing data. You will be expected to contribute to the interpretation of biophysical experiments on the basis of detailed analysis, to acquire an in-depth knowledge of the background literature, and to integrate the results of your data with those of ongoing molecular biology and biochemistry experiments in the field. A strong background in biophysics or biochemistry is a necessity. A good command of spoken and written English is a must. 


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

For more information about this position please contact Lab Manager Dr. Belen Solano Hermosilla, phone: +31 (0)15-2786489, e-mail: b.p.solanohermosilla@tudelft.nl.

Applications should include a letter of application, a detailed CV, and the names and contact information of three references. Applications will be evaluated on a first-come, first-serve basis. Please send the application by email to Lab Manager Dr. Belen Solano Hermosilla, e-mail: b.p.solanohermosilla@tudelft.nl. When applying for this position, please refer to vacancy number TNWBN18-049.