1. Vacatures
  2. Technische Universiteit Delft (TUD)
  3. PhD on Flow and Deformation of Cancer Cells

Helaas, deze vacature staat inmiddels niet meer online

Kijk gerust verder naar andere vacatures.

PhD on Flow and Deformation of Cancer Cells

Project Background: Often primary tumors do not kill patient, but secondary tumors do. These so-called metastatic tumor cells detach from a tumor and migrate …

ongeveer 2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Lorentzweg, Delft, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Salarisindicatie:
€ 2325 - € 2972 per maand
Opleidingsniveau:
WO

Functieomschrijving

Project Background: Often primary tumors do not kill patient, but secondary tumors do. These so-called metastatic tumor cells detach from a tumor and migrate through a complex environment, ultimately, prove fatal. Currently, we do not understand the fundamental of the mechanical pathways.  Your challenge is to understand the mechanics of cancer invasion at (sub-) cellular level. This is excellent topic to further your training in cell biology, biophysics and engineering, because you will need all three to describe coupling between cell migration and intracellular bio-polymer dynamics during/after cancer invasion in the presence of physical forces.

Project goal and description:

Unravelling the viscoelastic response of cancer and normal cells during flow

Cells inside a solid tumor behave like glassy materials with viscoelastic properties. Here, this PhD student will capture flow and deformation of cellular systems at microscopic level, using rheometric tools integrated with advanced microscopy techniques. In addition, PhD researcher will employ microfluidic techniques to characterize the rheological response of cancer cells during shear and channel flow.

Keywords: Rheology, Microfluidics, Non-linear viscoelasticity, mechanical properties of cells. 

Functie-eisen

We are looking for a PhD student with interest in the areas of microscale fluid dynamics, biophysics, and soft matter physics. You should have:

  • a MSc degree in biophysics, chemical engineering, mechanical engineering or a similar discipline, with excellent laboratory skills (preferably rheology, microscopy and microfluidics).
  • a strong theoretical background in rheology, biophysics, and preferably complemented with a good understanding of soft matter physics.
  • a curious mind-set, are self-driven, not afraid to take initiative, and able to easily communicate with others.
  • a high English proficiency in speaking, writing and reading

Conditions

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

Additional information

In case you have questions on the contents of this project, please contact Pouyan Boukany, the PI on this project, directly through: p.e.boukany@tudelft.nl.