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PhD/Post-doc: Chaperone-Mediated Protein Folding

Chaperone mechanisms in protein chains

2 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Mekelweg, Delft, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
40 uur
Opleidingsniveau:
WO

Functieomschrijving

Chaperones are central to protein folding, maintenance, and disease, but how and when they affect protein chains has remained difficult to study directly. Recently it has become possible to detect protein conformational changes mediated by chaperones, as we have shown at the single-molecule level using optical tweezers for SecB, Trigger Factor, and Hsp70 (Science 2007, Nature 2013, Nature 2016). A recent extension by integrating single-molecule fluorescence now allows us to visualise the composition of dynamic chaperone-client complexes and their effects on client states. In this project, we will apply this approach to determine the mechanisms underlying chaperone foldase action for a range of other intriguing chaperone systems and protein clients.

The position is intended as a full-time appointment. The formal employment and main activities will take place at AMOLF in Amsterdam. The student will participate in the TU Delft graduate school, and the PhD degree will be granted at the TU Delft.

Functie-eisen

We are looking for an outstanding experimental physicist or chemist with an interest in single-molecule biophysics and a strong drive to excel in a competitive, international environment. For a post-doctoral appointment you must have a PhD degree. Good communication skills in English are required.

Conditions

The PhD position is intended as full-time (40 hrs/week, 12 months/year) appointment at AMOLF for the duration of four years; a post-doctoral appointment is for two years.
AMOLF assists any new post-doc with housing and visa applications and compensates their transport costs.
As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

For more information about this position, please contact Prof. Sander Tans, phone: +31 (0)20-7547100, e-mail:
tans@amolf.nl., https://amolf.nl/research-groups/biophysics. Please apply through this site for the Postdoc position:
https://amolf.nl/jobs/seeing-and-sensing-chaperone-mediated-protein-folding-acceleration-2 and for the PhD position:
https://amolf.nl/jobs/seeing-and-sensing-chaperone-mediated-protein-folding-acceleration.

Additional information

Sander Tans
+31 (0)20-7547100
tans@amolf.nl

Technische Universiteit Delft

Bedrijfsomschrijving

Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools. Applied Sciences AMOLF performs leading fundamental research on the physics of biomolecular systems and nanophotonics, two areas with key potential for technological innovations. The Institute contributes to knowledge transfer to industry and society and trains talented young researchers. AMOLF is located at Science Park Amsterdam, the Netherlands, and engages approximately 140 scientists and a support staff of 70. See also www.amolf.nl.