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  3. PhD: Self-organization as a buffer for evolution, using cell polarity as a model

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PhD: Self-organization as a buffer for evolution, using cell polarity as a model

Core cellular functions are maintained during the course of evolution, even if essential proteins are lost or diversify, or new proteins are gained. How this …

3 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Mekelweg, Delft, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Salarisindicatie:
€ 2395 - € 3061 per maand
Opleidingsniveau:
WO

Functieomschrijving

Core cellular functions are maintained during the course of evolution, even if essential proteins are lost or diversify, or new proteins are gained. How this is achieved is a completely open question. One possibility is that self-organization buffers cellular functions against evolutionary changes in individual prioteins. Self-organization is the dynamic organization that emerges from the collective behavior of components, which individually cannot account for the final dynamic pattern. In this project we use the polarity network in budding yeast as a model to study the role of self-organization on evolution. During polarity establishment, a network of proteins self-organizes into a protein pattern on the cell membrane, which marks the site of daughter cell emergence. This process is vital for proliferation. In this pioneering project you will to study how much the spatial-temporal organization of the polarity machinery changes (due to self-organization) during a previously established evolutionary trajectory. To achieve this goal you will establish high throughput life cell microscopy and super resolution microscopy assays, set-up quantitative data analysis methods and collaborate with other group members for yeast genetics.

Functie-eisen

We are looking for an experimentalist who is eager to combine microscopy and data analysis and has a keen interest in evolutionary biophysics. We are a highly collaborative research group that likes to work on challenging and ambitious problems, that typically combine experiments with computational work. We expect the candidate to have an independent and well-organized work style, to be communicative, and to contribute to our open, interactive, and social lab culture. Applicants are invited to submit an email including cover letter, CV with publication list, and names/email addresses of 3 or more references, to Liedewij Laan (l.laan@tudelft.nl).

www.tudelft.nl/laanlab

Conditions

TU Delft offers an attractive benefits package, including a flexible work week, free high-speed Internet access from home (with a contract of two years or longer), and the option of assembling a customised compensation and benefits package. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities. Delft University of Technology strives to increase the number of women in higher academic positions; women are therefore especially encouraged to apply.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.phd.tudelft.nl for more information.

Additional information

For more information about this position, please contact Dr. ir. Liedewij Laan, phone: +31 (0)15-2782856 , e-mail: l.laan@tudelft.nl.