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PhD student in Structural Biology of Host-Pathogen Interactions

We are looking for highly motivated PhD candidates to join the newly established Electron Nanoscopy group of Dr. Arjen Jakobi at the Department of Bionanoscience, Kavli Institute of Nanoscience Delft (https://cryoem.tudelft.nl). The ...

4 maanden geleden

Arbeidsvoorwaarden

Standplaats:
Mekelweg, Delft, Zuid-Holland
Dienstverband:
Tijdelijk contract / Tijdelijke opdracht
Uren per week:
38 - 38 uur
Salarisindicatie:
€ 2222 - € 2840 per maand
Opleidingsniveau:
WO

Functieomschrijving

We are looking for highly motivated PhD candidates to join the newly established Electron Nanoscopy group of Dr. Arjen Jakobi at the Department of Bionanoscience, Kavli Institute of Nanoscience Delft (https://cryoem.tudelft.nl). The laboratory is using a structural biology approach that integrates cryo-EM imaging, electron/X-ray diffraction, and protein biochemistry methods to study molecular mechanisms of the host machinery mediating defense against invading pathogens. We also develop and apply new approaches for cryo-EM and diffraction methods to facilitate meeting our research goals.

Projects in the lab will involve purification of key molecules mediating intracellular immunity and their characterization using state-of-the-art structural biology techniques, as well as structural and functional validation in cellular model systems. Training will be provided in molecular biology, protein biochemistry, cryo-EM/-ET and associated image-processing techniques as well as X-ray crystallography. There will be flexibility to tailor projects to the experience and interests of the applicant. Opportunities exist also for more technically/computationally oriented projects for candidates with such interest. A contract for 4 years will be offered to the successful candidates.

We offer a dynamic, supportive and collegial environment with access to state-of-the art facilities. The Department of Bionanoscience will provide outstanding infrastructure for molecular biology, biochemistry, electron microscopy and high-performance computing for image processing.

Functie-eisen

The candidate should have a degree in biology, biochemistry, chemistry, physics or a related field, with research experience in molecular biology and enthusiasm for working at the interface of biology, chemistry, and physics. Expertise in recombinant protein expression is strongly desired. Previous experience with electron microscopy or X-ray crystallography is beneficial, but not required. We are looking for a candidate with a high level of intellectual creativity and genuine interest in fundamental research that has the motivation and ability to work in an international and interdisciplinary team. Good communication skills in English are essential.

Conditions

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

For more information about this position, please contact Dr. Arjen Jakobi, phone: +31 (0)15 2789249, e-mail: a.jakobi@tudelft.nl. To apply, please e-mail a detailed CV, letter of motivation and names of three references by 15 March 2018 to Arjen Jakobi, a.jakobi@tudelft.nl. When applying for this position, please refer to vacancy number TNWBN18-012.

Bedrijfsomschrijving

Faculty Applied Sciences

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The Department of Bionanoscience, part of the Faculty of Applied Sciences at Delft University of Technology and part of the Kavli Institute of Nanoscience Delft (https://www.kavli.nl), is dedicated to pioneering, fundamental research at the interface between physics and biology. This young, international department was established in 2010 and has since expanded to currently 15 faculty members. The department offers excellent general facilities, including an advanced optical microscopy facility, a cryo-EM facility, extensive general cell biology and biochemistry facilities, and a large cleanroom facility, the Kavli Nanolab Delft. The department strives for a collegial, nourishing, and inclusive environment.