Promovendus bij de Faculteit Health, Medicine and Life Sciences, School CAPHRI, Vakgroep Gezondheidsbevordering
Ongeveer 6 uur geleden - Universiteit Maastricht - Maastricht
Engineering microbial biosynthesis of isoprenoid-based compounds
We seek a highly motivated post-doctoral researcher to engineer microbial biosynthesis of isoprenoid-based compounds. Improvements in microbial engineering are accelerating the global transition to a sustainable bio-based economy. However, the development of biosynthesis platforms is often hindered by incompatibilities between metabolic pathways and heterologous hosts. This barrier, which has remained largely unaddressed, limits the range of products that can be manufactured using engineered microbes and slows our exploitation of Nature’s full catalytic potential.
Working in collaboration with an international consortium of four research labs, the post-doc will identify orthologs of key biosynthetic enzymes and associated cofactors via genome mining. The post-doc will use these orthologs and cofactors to improve the performance of an isoprenoid biosynthesis platform. Finally, working with our industrial partner, the post-doc will test the strains with pilot-scale fermentations. This position affords a unique opportunity, as it will identify solutions to a fundamental bioengineering problem and immediately assess those solutions within an industrial setting. The post-doc will be encouraged to pursue independent research directions within this framework.
The candidate must have a PhD degree in the field of bioengineering, metabolic engineering, biochemistry, microbiology, or a related field. Experience with bioinformatics, synthetic biology, metabolic engineering, high-throughput screens, or chromatography, as indicated by a successful track record of publications, is highly desirable. Experience with cultivating or genetic engineering of alpha-Proteobacteria is desirable but not required. We are especially interested in candidates with a background in iron-sulfur enzyme biology or biochemistry. The position will be for a fixed term of 30 months and is intended as full-time. Good communication skills in English are required.
The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.
For more information about this position, please contact Dr. Greg Bokinsky, e-mail: firstname.lastname@example.org. To apply, please send your resume and motivation letter describing how this project fits your interests (max. 1 page) - to Dr. Bokinsky, email@example.com, by 15 February 2018. Applications without a motivation letter will not be considered.
Please quote vacancy number TNWBN18-006 in the subject line of your e-mail. Online screening may be part of the selection.
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Technische Universiteit Delft
Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools.Faculty Applied Sciences
The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.
The Department of Bionanoscience is comprised of independent research labs who are dedicated to research at the interface between nanoscience, synthetic biology, and cell biology. It studies single cells in all their complexity down to the molecular level, from both fundamental scientific and application points of view. The department operates as part of the Kavli Institute of Nanoscience at the Faculty of Applied Sciences and aims at a leading international position. The Bokinsky Lab specialises in bacterial metabolic engineering, as well as understanding metabolic flux and growth rate control and growth rate sensing.